Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
hemBPorphobilinogen synthase; KEGG: aae:aq_2109 1.1e-102 hemB; delta-aminolevulinic acid dehydratase K01698; COG: COG0113 Delta-aminolevulinic acid dehydratase; Psort location: Cytoplasmic, score: 8.87; Belongs to the ALAD family. (325 aa)    
Predicted Functional Partners:
hemC
Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
 
 
 0.998
SirC
Siroheme synthase domain protein; KEGG: aae:aq_1237 6.8e-23 cysG; precorrin-2 oxidase.
 
   
 0.971
cbiK
Cobalt chelatase (CbiK); KEGG: lin:lin1165 4.1e-55 cbiK; similar to anaerobic Cobalt Chelatase In Cobalamin Biosynthesis K02190; COG: COG4822 Cobalamin biosynthesis protein CbiK, Co2+ chelatase; Psort location: Cytoplasmic, score: 8.87.
 
   
 0.816
hemE_2
Methyltransferase, MtaA/CmuA family; KEGG: mmp:MMP0831 8.5e-103 mtbA; uroporphyrinogen decarboxylase (URO-D) K00599; COG: COG0407 Uroporphyrinogen-III decarboxylase; Psort location: Cytoplasmic, score: 8.87.
  
 
 0.589
cobM
KEGG: mta:Moth_1092 1.4e-68 precorrin-4 C11-methyltransferase K03396; COG: COG2875 Precorrin-4 methylase.
 
   
 0.583
nuoE_1
Putative NADH dehydrogenase subunit E; KEGG: pca:Pcar_0207 2.3e-13 ATP synthase subunit E K00334; COG: COG1905 NADH:ubiquinone oxidoreductase 24 kD subunit; Psort location: Cytoplasmic, score: 8.87.
       0.543
hisE
phosphoribosyl-ATP diphosphatase; KEGG: sao:SAOUHSC_03008 3.6e-56 imidazole glycerol phosphate synthase subunit HisF, putative K01663; COG: COG0139 Phosphoribosyl-AMP cyclohydrolase; Psort location: Cytoplasmic, score: 9.98; In the C-terminal section; belongs to the PRA-PH family.
  
  
 0.538
folK
2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin.
  
  
 0.512
ntpJ
KEGG: shn:Shewana3_0031 4.6e-08 potassium uptake protein, TrkH family K00961; COG: COG0168 Trk-type K+ transport systems, membrane components; Psort location: CytoplasmicMembrane, score: 10.00.
       0.512
EDS05009.1
Hypothetical protein.
       0.506
Your Current Organism:
Clostridium scindens
NCBI taxonomy Id: 411468
Other names: Clostridium scindens ATCC 35704, [. scindens ATCC 35704, [Clostridium] scindens ATCC 35704
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