Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
clpCATPase family associated with various cellular activities (AAA); KEGG: sab:SAB0475 4.3e-227 clpC; endopeptidase K03696; COG: COG0542 ATPases with chaperone activity, ATP-binding subunit; Psort location: Cytoplasmic, score: 9.98; Belongs to the ClpA/ClpB family. (812 aa)    
Predicted Functional Partners:
dnaK
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
 
 
 0.965
clpP-4
ATP-dependent Clp endopeptidase, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.
 
 
 0.843
mecB
COG: COG4862 Negative regulator of genetic competence, sporulation and motility; Psort location: Cytoplasmic, score: 8.87.
    
 
 0.840
YtrA_1
KEGG: btk:BT9727_3817 6.4e-11 transcriptional regulator, GntR family K07979; COG: COG1725 Predicted transcriptional regulators; Psort location: Cytoplasmic, score: 8.87.
       0.830
clpP-2
KEGG: lsl:LSL_0785 5.6e-35 clpP; ATP-dependent Clp protease proteolytic subunit K01358; COG: COG0740 Protease subunit of ATP-dependent Clp proteases; Psort location: Cytoplasmic, score: 9.65; Belongs to the peptidase S14 family.
 
 
 0.829
clpP
KEGG: bca:BCE_0399 2.9e-54 clpP; ClpP protease family protein K01358; COG: COG0740 Protease subunit of ATP-dependent Clp proteases; Psort location: Cytoplasmic, score: 9.65; Belongs to the peptidase S14 family.
 
 
 0.820
clpP-3
KEGG: lsl:LSL_0785 2.8e-24 clpP; ATP-dependent Clp protease proteolytic subunit K01358; COG: COG0740 Protease subunit of ATP-dependent Clp proteases; Psort location: Cytoplasmic, score: 8.87; Belongs to the peptidase S14 family.
  
 
 0.797
grpE
Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...]
  
 
 0.782
EDS05973.1
Hsp20/alpha crystallin family protein; COG: COG0071 Molecular chaperone (small heat shock protein); Belongs to the small heat shock protein (HSP20) family.
  
 
 0.748
EDS04883.1
Hsp20/alpha crystallin family protein; COG: COG0071 Molecular chaperone (small heat shock protein); Belongs to the small heat shock protein (HSP20) family.
  
 
 0.748
Your Current Organism:
Clostridium scindens
NCBI taxonomy Id: 411468
Other names: Clostridium scindens ATCC 35704, [. scindens ATCC 35704, [Clostridium] scindens ATCC 35704
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