STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tdkThymidine kinase; KEGG: cpe:CPE2204 2.1e-60 tdk; thymidine kinase K00857; Psort location: Cytoplasmic, score: 8.96. (204 aa)    
Predicted Functional Partners:
dut
dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family.
   
 
 0.944
EFB76715.1
Hypothetical protein; KEGG: ctc:CTC00220 3.8e-52 thymidylate kinase K00943.
  
 
 0.936
cdd
Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.
 
  
 0.930
EFB76444.1
Cytidine and deoxycytidylate deaminase zinc-binding region; KEGG: dps:DP2271 3.3e-53 probable deoxycytidylate deaminase K01493.
  
 
 0.926
pyn
KEGG: gka:GK2312 2.8e-120 pyrimidine-nucleoside phosphorylase (PYNP) K00756.
    
 0.867
deoD
KEGG: ftl:FTL_1461 3.5e-58 purine nucleoside phosphorylase K03784.
  
 
 0.857
thyX
Thymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
    
 0.845
prfA
Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
  
  
 0.836
EFB74757.1
Hypothetical protein; KEGG: bur:Bcep18194_A4171 2.5e-06 alpha/beta hydrolase K01054.
    
 0.830
EFB76822.1
Purine nucleoside phosphorylase I, inosine and guanosine-specific; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
    
  0.821
Your Current Organism:
Subdoligranulum variabile
NCBI taxonomy Id: 411471
Other names: S. variabile DSM 15176, Subdoligranulum variabile DSM 15176
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.