STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ERJ96088.1Branched-chain-amino-acid transaminase; KEGG: ral:Rumal_2344 3.3e-146 branched-chain amino acid aminotransferase K00826; Psort location: Cytoplasmic, score: 7.50. (356 aa)    
Predicted Functional Partners:
ilvD
KEGG: ral:Rumal_2870 4.9e-239 dihydroxy-acid dehydratase K01687; Psort location: Cytoplasmic, score: 7.50; Belongs to the IlvD/Edd family.
  
 0.995
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
  
 0.974
trpD
Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA).
  
 
 0.966
ERJ96636.1
KEGG: ral:Rumal_2960 3.8e-74 Prephenate dehydratase K14170; Psort location: Cytoplasmic, score: 9.97.
  
 
 0.962
ERJ90777.1
HMGL-like protein; KEGG: eel:EUBELI_01913 6.8e-107 hypothetical protein; K01666 4-hydroxy 2-oxovalerate aldolase; Psort location: Cytoplasmic, score: 9.97.
  
 0.943
ERJ97484.1
Threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
  
 
 0.939
ERJ88653.1
KEGG: eha:Ethha_2767 1.3e-103 homoserine dehydrogenase; K00003 homoserine dehydrogenase; Psort location: Cytoplasmic, score: 7.50.
  
 
 0.932
ERJ90963.1
3-methyl-2-oxobutanoate dehydrogenase; KEGG: eha:Ethha_0233 1.1e-122 pyruvate flavodoxin/ferredoxin oxidoreductase domain-containing protein; K00174 2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Psort location: Cytoplasmic, score: 7.50.
  
 
  0.898
ERJ94846.1
KEGG: eel:EUBELI_20125 6.3e-88 thrH; phosphoserine phosphatase; K02203 phosphoserine / homoserine phosphotransferase; Psort location: Cytoplasmic, score: 7.50.
    
 0.887
trpE
Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...]
  
 
 0.872
Your Current Organism:
Ruminococcus callidus
NCBI taxonomy Id: 411473
Other names: R. callidus ATCC 27760, Ruminococcus callidus ATCC 27760
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