STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ERJ93261.1Hydrolase, NUDIX family; KEGG: str:Sterm_2202 8.5e-24 polynucleotide adenylyltransferase/metal dependent phosphohydrolase; K00974 tRNA nucleotidyltransferase (CCA-adding enzyme); Psort location: Cytoplasmic, score: 7.50. (136 aa)    
Predicted Functional Partners:
ERJ96677.1
Pyruvate kinase; KEGG: ral:Rumal_3948 2.0e-169 pyruvate kinase K00873; Psort location: Cytoplasmic, score: 7.50.
 
 
  0.843
nadE
NAD+ synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
  
 
 0.823
folE
KEGG: ral:Rumal_0212 4.4e-64 GTP cyclohydrolase I K01495; Psort location: Cytoplasmic, score: 7.50.
  
 
 0.813
ERJ92525.1
Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
  
 
 0.812
ERJ96932.1
Competence/damage-inducible protein CinA domain protein; KEGG: cco:CCC13826_0279 1.7e-17 fadD; long-chain-fatty-acid--CoA ligase K03743; Psort location: Cytoplasmic, score: 7.50; Belongs to the CinA family.
    
 0.810
ERJ94442.1
Putative GTP diphosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
     
 0.798
pyrG
CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
    
  0.797
ERJ93793.1
KEGG: ral:Rumal_3726 2.4e-269 homocysteine S-methyltransferase; K00548 5-methyltetrahydrofolate--homocysteine methyltransferase; Psort location: Cytoplasmic, score: 7.50.
    
 0.793
ribBA
GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
     
 0.790
ERJ96540.1
Dinuclear metal center protein, YbgI family; KEGG: hip:CGSHiEE_02770 9.5e-14 seryl-tRNA synthetase; Psort location: Cytoplasmic, score: 7.50.
    
  0.781
Your Current Organism:
Ruminococcus callidus
NCBI taxonomy Id: 411473
Other names: R. callidus ATCC 27760, Ruminococcus callidus ATCC 27760
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