| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EDP26286.1 | EDP26479.1 | COPEUT_01829 | COPEUT_01449 | Amidohydrolase family protein; KEGG: mma:MM2279 4.1e-55 N-ethylammeline chlorohydrolase K01564; COG: COG0402 Cytosine deaminase and related metal-dependent hydrolases; Psort location: Cytoplasmic, score:8.87. | Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding domain protein; KEGG: eco:b2881 2.4e-123 xdhD, ygfN; possible hypoxanthine oxidase; COG: COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs; Psort location: CytoplasmicMembrane, score:9.49. | 0.955 |
| EDP26286.1 | EDP27473.1 | COPEUT_01829 | COPEUT_00182 | Amidohydrolase family protein; KEGG: mma:MM2279 4.1e-55 N-ethylammeline chlorohydrolase K01564; COG: COG0402 Cytosine deaminase and related metal-dependent hydrolases; Psort location: Cytoplasmic, score:8.87. | Purine nucleoside phosphorylase I, inosine and guanosine-specific; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.959 |
| EDP26286.1 | apt | COPEUT_01829 | COPEUT_01041 | Amidohydrolase family protein; KEGG: mma:MM2279 4.1e-55 N-ethylammeline chlorohydrolase K01564; COG: COG0402 Cytosine deaminase and related metal-dependent hydrolases; Psort location: Cytoplasmic, score:8.87. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.932 |
| EDP26286.1 | gmk | COPEUT_01829 | COPEUT_01401 | Amidohydrolase family protein; KEGG: mma:MM2279 4.1e-55 N-ethylammeline chlorohydrolase K01564; COG: COG0402 Cytosine deaminase and related metal-dependent hydrolases; Psort location: Cytoplasmic, score:8.87. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.411 |
| EDP26286.1 | hpt | COPEUT_01829 | COPEUT_00801 | Amidohydrolase family protein; KEGG: mma:MM2279 4.1e-55 N-ethylammeline chlorohydrolase K01564; COG: COG0402 Cytosine deaminase and related metal-dependent hydrolases; Psort location: Cytoplasmic, score:8.87. | KEGG: sco:SCO3405 5.4e-46 hprT, SCE9.12c; putative hypoxanthine phosphoribosyltransferase K00760; COG: COG0634 Hypoxanthine-guanine phosphoribosyltransferase; Psort location: Cytoplasmic, score:9.98; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.946 |
| EDP26286.1 | xpt | COPEUT_01829 | COPEUT_02027 | Amidohydrolase family protein; KEGG: mma:MM2279 4.1e-55 N-ethylammeline chlorohydrolase K01564; COG: COG0402 Cytosine deaminase and related metal-dependent hydrolases; Psort location: Cytoplasmic, score:8.87. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.932 |
| EDP26479.1 | EDP26286.1 | COPEUT_01449 | COPEUT_01829 | Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding domain protein; KEGG: eco:b2881 2.4e-123 xdhD, ygfN; possible hypoxanthine oxidase; COG: COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs; Psort location: CytoplasmicMembrane, score:9.49. | Amidohydrolase family protein; KEGG: mma:MM2279 4.1e-55 N-ethylammeline chlorohydrolase K01564; COG: COG0402 Cytosine deaminase and related metal-dependent hydrolases; Psort location: Cytoplasmic, score:8.87. | 0.955 |
| EDP26479.1 | xpt | COPEUT_01449 | COPEUT_02027 | Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding domain protein; KEGG: eco:b2881 2.4e-123 xdhD, ygfN; possible hypoxanthine oxidase; COG: COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs; Psort location: CytoplasmicMembrane, score:9.49. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.930 |
| EDP27473.1 | EDP26286.1 | COPEUT_00182 | COPEUT_01829 | Purine nucleoside phosphorylase I, inosine and guanosine-specific; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | Amidohydrolase family protein; KEGG: mma:MM2279 4.1e-55 N-ethylammeline chlorohydrolase K01564; COG: COG0402 Cytosine deaminase and related metal-dependent hydrolases; Psort location: Cytoplasmic, score:8.87. | 0.959 |
| EDP27473.1 | apt | COPEUT_00182 | COPEUT_01041 | Purine nucleoside phosphorylase I, inosine and guanosine-specific; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.969 |
| EDP27473.1 | guaA | COPEUT_00182 | COPEUT_02596 | Purine nucleoside phosphorylase I, inosine and guanosine-specific; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | 0.586 |
| EDP27473.1 | guaB | COPEUT_00182 | COPEUT_01719 | Purine nucleoside phosphorylase I, inosine and guanosine-specific; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.543 |
| EDP27473.1 | hpt | COPEUT_00182 | COPEUT_00801 | Purine nucleoside phosphorylase I, inosine and guanosine-specific; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | KEGG: sco:SCO3405 5.4e-46 hprT, SCE9.12c; putative hypoxanthine phosphoribosyltransferase K00760; COG: COG0634 Hypoxanthine-guanine phosphoribosyltransferase; Psort location: Cytoplasmic, score:9.98; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.972 |
| EDP27473.1 | xpt | COPEUT_00182 | COPEUT_02027 | Purine nucleoside phosphorylase I, inosine and guanosine-specific; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.969 |
| apt | EDP26286.1 | COPEUT_01041 | COPEUT_01829 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Amidohydrolase family protein; KEGG: mma:MM2279 4.1e-55 N-ethylammeline chlorohydrolase K01564; COG: COG0402 Cytosine deaminase and related metal-dependent hydrolases; Psort location: Cytoplasmic, score:8.87. | 0.932 |
| apt | EDP27473.1 | COPEUT_01041 | COPEUT_00182 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Purine nucleoside phosphorylase I, inosine and guanosine-specific; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.969 |
| apt | gmk | COPEUT_01041 | COPEUT_01401 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.960 |
| apt | guaA | COPEUT_01041 | COPEUT_02596 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | 0.991 |
| apt | guaB | COPEUT_01041 | COPEUT_01719 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.911 |
| apt | hisE | COPEUT_01041 | COPEUT_00260 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | phosphoribosyl-ATP diphosphatase; KEGG: sao:SAOUHSC_03008 9.1e-67 imidazole glycerol phosphate synthase subunit HisF, putative K01663; COG: COG0139 Phosphoribosyl-AMP cyclohydrolase; Psort location: Cytoplasmic, score:9.98; In the C-terminal section; belongs to the PRA-PH family. | 0.957 |