STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gph-4Glycoside/pentoside/hexuronide transporter; KEGG: eci:UTI89_C4210 3.7e-38 yicJ; hypothetical symporter YicJ K03292; COG: COG2211 Na+/melibiose symporter and related transporters; Psort location: CytoplasmicMembrane, score: 10.00. (467 aa)    
Predicted Functional Partners:
EDR98272.1
Lactose permease family protein; KEGG: eci:UTI89_C4210 4.5e-09 yicJ; hypothetical symporter YicJ K03292; COG: COG2211 Na+/melibiose symporter and related transporters; Psort location: CytoplasmicMembrane, score: 10.00.
  
     0.772
EDR96463.1
Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
    
  0.737
EDR96912.1
Oxidoreductase, NAD-binding domain protein; KEGG: ctc:CTC00511 8.5e-119 myo-inositol 2-dehydrogenase K00010; COG: COG0673 Predicted dehydrogenases and related proteins; Psort location: Cytoplasmic, score: 8.87.
     
 0.642
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
    
  0.531
EDR97589.1
5'-nucleotidase, C-terminal domain protein; KEGG: rle:RL4075 7.0e-19 putative 5'-nucleotidase K01081; COG: COG0737 5-nucleotidase/2,3-cyclic phosphodiesterase and related esterases; Psort location: Cellwall, score: 9.17.
  
 
 0.530
tmk
dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
    
 0.529
dut
dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
    
 0.515
EDR96462.1
Ribonucleoside-diphosphate reductase, beta subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family.
    
  0.466
nrdD-3
KEGG: tde:TDE1331 2.0e-220 nrdD; anaerobic ribonucleoside triphosphate reductase K00527; COG: COG1328 Oxygen-sensitive ribonucleoside-triphosphate reductase; Psort location: Cytoplasmic, score: 8.87.
    
  0.455
nrdD
KEGG: ssn:SSO_4419 5.6e-122 nrdD; anaerobic ribonucleoside-triphosphate reductase K00527; COG: COG1328 Oxygen-sensitive ribonucleoside-triphosphate reductase; Psort location: Cytoplasmic, score: 8.87.
    
  0.430
Your Current Organism:
Anaerostipes caccae
NCBI taxonomy Id: 411490
Other names: A. caccae DSM 14662, Anaerostipes caccae DSM 14662
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