node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SDS00837.1 | SDT31712.1 | SAMN04489834_0689 | SAMN04489834_3416 | D-serine deaminase, pyridoxal phosphate-dependent. | Pyruvate dehydrogenase (quinone); Belongs to the TPP enzyme family. | 0.801 |
SDS44283.1 | SDT31712.1 | SAMN04489834_1490 | SAMN04489834_3416 | Acetolactate synthase, small subunit. | Pyruvate dehydrogenase (quinone); Belongs to the TPP enzyme family. | 0.947 |
SDS44283.1 | leuA | SAMN04489834_1490 | SAMN04489834_2319 | Acetolactate synthase, small subunit. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.850 |
SDS44283.1 | leuC | SAMN04489834_1490 | SAMN04489834_1590 | Acetolactate synthase, small subunit. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.866 |
SDS46612.1 | SDT31712.1 | SAMN04489834_1532 | SAMN04489834_3416 | Acyl-CoA reductase; Belongs to the aldehyde dehydrogenase family. | Pyruvate dehydrogenase (quinone); Belongs to the TPP enzyme family. | 0.911 |
SDS46612.1 | acsA | SAMN04489834_1532 | SAMN04489834_3272 | Acyl-CoA reductase; Belongs to the aldehyde dehydrogenase family. | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.931 |
SDS68038.1 | SDS79582.1 | SAMN04489834_1929 | SAMN04489834_2170 | Pyruvate kinase; Belongs to the pyruvate kinase family. | Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.930 |
SDS68038.1 | SDS90379.1 | SAMN04489834_1929 | SAMN04489834_2402 | Pyruvate kinase; Belongs to the pyruvate kinase family. | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | 0.961 |
SDS68038.1 | SDT28684.1 | SAMN04489834_1929 | SAMN04489834_3316 | Pyruvate kinase; Belongs to the pyruvate kinase family. | Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.930 |
SDS68038.1 | SDT31712.1 | SAMN04489834_1929 | SAMN04489834_3416 | Pyruvate kinase; Belongs to the pyruvate kinase family. | Pyruvate dehydrogenase (quinone); Belongs to the TPP enzyme family. | 0.925 |
SDS68038.1 | leuA | SAMN04489834_1929 | SAMN04489834_2319 | Pyruvate kinase; Belongs to the pyruvate kinase family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.836 |
SDS68038.1 | leuC | SAMN04489834_1929 | SAMN04489834_1590 | Pyruvate kinase; Belongs to the pyruvate kinase family. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.824 |
SDS79582.1 | SDS68038.1 | SAMN04489834_2170 | SAMN04489834_1929 | Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Pyruvate kinase; Belongs to the pyruvate kinase family. | 0.930 |
SDS79582.1 | SDS90379.1 | SAMN04489834_2170 | SAMN04489834_2402 | Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | 0.920 |
SDS79582.1 | SDT28684.1 | SAMN04489834_2170 | SAMN04489834_3316 | Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.921 |
SDS79582.1 | SDT31712.1 | SAMN04489834_2170 | SAMN04489834_3416 | Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Pyruvate dehydrogenase (quinone); Belongs to the TPP enzyme family. | 0.902 |
SDS79582.1 | acsA | SAMN04489834_2170 | SAMN04489834_3272 | Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.819 |
SDS79582.1 | leuA | SAMN04489834_2170 | SAMN04489834_2319 | Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.817 |
SDS79582.1 | leuC | SAMN04489834_2170 | SAMN04489834_1590 | Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.804 |
SDS90379.1 | SDS68038.1 | SAMN04489834_2402 | SAMN04489834_1929 | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | Pyruvate kinase; Belongs to the pyruvate kinase family. | 0.961 |