Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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dnaNDNA polymerase III beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (367 aa)    
Predicted Functional Partners:
holB
DNA polymerase III delta prime subunit.
 
 0.997
dnaE
DNA polymerase III alpha subunit.
  
 
 0.996
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
 
 0.995
holA
DNA polymerase III delta subunit.
  
 
 0.995
dnaX
DNA polymerase III tau and gamma subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
   
 0.995
dnaQ
DNA polymerase III epsilon subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease.
   
 0.993
COSY_0252
DnaA family protein; ATPase involved in DNA replication initiation, DnaA family protein; Belongs to the DnaA family.
  
 
 0.971
dnaA
Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family.
  
 
 0.951
dinG
ATP-dependent DNA helicase DinG; DNA-dependent ATPase and 5'-3' DNA helicase.
    
 0.915
xthA
Exodeoxyribonuclease III.
   
 0.875
Your Current Organism:
Vesicomyosocius okutanii
NCBI taxonomy Id: 412965
Other names: C. Vesicomyosocius okutanii HA, Calyptogena okutanii thioautotrophic gill symbiont HA, Candidatus Vesicomyosocius okutanii HA, Candidatus Vesicomyosocius okutanii str. HA, Candidatus Vesicomyosocius okutanii strain HA
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