node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
COSY_0495 | COSY_0496 | COSY_0495 | COSY_0496 | Conserved hypothetical protein; Similar to MoxR-like ATPase. | Conserved hypothetical protein; Belongs to the UPF0250 family. | 0.557 |
COSY_0495 | lipA | COSY_0495 | COSY_0498 | Conserved hypothetical protein; Similar to MoxR-like ATPase. | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.557 |
COSY_0495 | lipB | COSY_0495 | COSY_0497 | Conserved hypothetical protein; Similar to MoxR-like ATPase. | Lipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. | 0.557 |
COSY_0496 | COSY_0495 | COSY_0496 | COSY_0495 | Conserved hypothetical protein; Belongs to the UPF0250 family. | Conserved hypothetical protein; Similar to MoxR-like ATPase. | 0.557 |
COSY_0496 | lipA | COSY_0496 | COSY_0498 | Conserved hypothetical protein; Belongs to the UPF0250 family. | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.807 |
COSY_0496 | lipB | COSY_0496 | COSY_0497 | Conserved hypothetical protein; Belongs to the UPF0250 family. | Lipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. | 0.836 |
aceF | gcvH | COSY_0863 | COSY_0829 | Pyruvate dehydrogenase complex E2 component; Dihydrolipoamide acetyltransferase. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.932 |
aceF | lipA | COSY_0863 | COSY_0498 | Pyruvate dehydrogenase complex E2 component; Dihydrolipoamide acetyltransferase. | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.442 |
aceF | lipB | COSY_0863 | COSY_0497 | Pyruvate dehydrogenase complex E2 component; Dihydrolipoamide acetyltransferase. | Lipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. | 0.455 |
aceF | nfuA | COSY_0863 | COSY_0386 | Pyruvate dehydrogenase complex E2 component; Dihydrolipoamide acetyltransferase. | Conserved hypothetical protein; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. | 0.454 |
gcvH | aceF | COSY_0829 | COSY_0863 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Pyruvate dehydrogenase complex E2 component; Dihydrolipoamide acetyltransferase. | 0.932 |
gcvH | lipA | COSY_0829 | COSY_0498 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.922 |
gcvH | lipB | COSY_0829 | COSY_0497 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Lipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. | 0.932 |
guaA | lipA | COSY_0820 | COSY_0498 | GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.461 |
guaA | nadE | COSY_0820 | COSY_0477 | GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. | NAD+ synthase (glutamine-hydrolysing); Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.635 |
guaA | nrdA | COSY_0820 | COSY_0479 | GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. | Ribonucleoside-diphosphate reductase alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.579 |
guaA | obg | COSY_0820 | COSY_0381 | GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. | GTP-binding protein, GTP1/Obg family; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. | 0.441 |
lipA | COSY_0495 | COSY_0498 | COSY_0495 | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | Conserved hypothetical protein; Similar to MoxR-like ATPase. | 0.557 |
lipA | COSY_0496 | COSY_0498 | COSY_0496 | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | Conserved hypothetical protein; Belongs to the UPF0250 family. | 0.807 |
lipA | aceF | COSY_0498 | COSY_0863 | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | Pyruvate dehydrogenase complex E2 component; Dihydrolipoamide acetyltransferase. | 0.442 |