node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rmag_0066 | Rmag_0446 | Rmag_0066 | Rmag_0446 | PFAM: pyruvate kinase; KEGG: vpa:VP2039 pyruvate kinase II; Belongs to the pyruvate kinase family. | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: dar:Daro_3074 acetolactate synthase, small subunit. | 0.800 |
Rmag_0066 | Rmag_0458 | Rmag_0066 | Rmag_0458 | PFAM: pyruvate kinase; KEGG: vpa:VP2039 pyruvate kinase II; Belongs to the pyruvate kinase family. | 2-oxo-acid dehydrogenase E1 subunit, homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.913 |
Rmag_0066 | Rmag_0819 | Rmag_0066 | Rmag_0819 | PFAM: pyruvate kinase; KEGG: vpa:VP2039 pyruvate kinase II; Belongs to the pyruvate kinase family. | Malate dehydrogenase (oxaloacetate-decarboxylating); PFAM: malic enzyme domain protein; malic enzyme, NAD-binding; KEGG: hch:HCH_05974 malic enzyme. | 0.954 |
Rmag_0066 | Rmag_0848 | Rmag_0066 | Rmag_0848 | PFAM: pyruvate kinase; KEGG: vpa:VP2039 pyruvate kinase II; Belongs to the pyruvate kinase family. | TIGRFAM: oxaloacetate decarboxylase alpha subunit; PFAM: biotin/lipoyl attachment domain-containing protein; pyruvate carboxyltransferase; Conserved carboxylase region; KEGG: pha:PSHAa0539 oxaloacetate decarboxylase. | 0.950 |
Rmag_0066 | ilvD | Rmag_0066 | Rmag_0529 | PFAM: pyruvate kinase; KEGG: vpa:VP2039 pyruvate kinase II; Belongs to the pyruvate kinase family. | KEGG: mca:MCA2082 dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.526 |
Rmag_0066 | leuA | Rmag_0066 | Rmag_0449 | PFAM: pyruvate kinase; KEGG: vpa:VP2039 pyruvate kinase II; Belongs to the pyruvate kinase family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.817 |
Rmag_0066 | leuC | Rmag_0066 | Rmag_0372 | PFAM: pyruvate kinase; KEGG: vpa:VP2039 pyruvate kinase II; Belongs to the pyruvate kinase family. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.803 |
Rmag_0066 | leuD | Rmag_0066 | Rmag_0371 | PFAM: pyruvate kinase; KEGG: vpa:VP2039 pyruvate kinase II; Belongs to the pyruvate kinase family. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.804 |
Rmag_0446 | Rmag_0066 | Rmag_0446 | Rmag_0066 | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: dar:Daro_3074 acetolactate synthase, small subunit. | PFAM: pyruvate kinase; KEGG: vpa:VP2039 pyruvate kinase II; Belongs to the pyruvate kinase family. | 0.800 |
Rmag_0446 | Rmag_0458 | Rmag_0446 | Rmag_0458 | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: dar:Daro_3074 acetolactate synthase, small subunit. | 2-oxo-acid dehydrogenase E1 subunit, homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.804 |
Rmag_0446 | Rmag_0819 | Rmag_0446 | Rmag_0819 | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: dar:Daro_3074 acetolactate synthase, small subunit. | Malate dehydrogenase (oxaloacetate-decarboxylating); PFAM: malic enzyme domain protein; malic enzyme, NAD-binding; KEGG: hch:HCH_05974 malic enzyme. | 0.811 |
Rmag_0446 | Rmag_0848 | Rmag_0446 | Rmag_0848 | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: dar:Daro_3074 acetolactate synthase, small subunit. | TIGRFAM: oxaloacetate decarboxylase alpha subunit; PFAM: biotin/lipoyl attachment domain-containing protein; pyruvate carboxyltransferase; Conserved carboxylase region; KEGG: pha:PSHAa0539 oxaloacetate decarboxylase. | 0.800 |
Rmag_0446 | ilvC | Rmag_0446 | Rmag_0447 | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: dar:Daro_3074 acetolactate synthase, small subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.998 |
Rmag_0446 | ilvD | Rmag_0446 | Rmag_0529 | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: dar:Daro_3074 acetolactate synthase, small subunit. | KEGG: mca:MCA2082 dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.780 |
Rmag_0446 | leuA | Rmag_0446 | Rmag_0449 | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: dar:Daro_3074 acetolactate synthase, small subunit. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.963 |
Rmag_0446 | leuB | Rmag_0446 | Rmag_0099 | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: dar:Daro_3074 acetolactate synthase, small subunit. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.985 |
Rmag_0446 | leuC | Rmag_0446 | Rmag_0372 | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: dar:Daro_3074 acetolactate synthase, small subunit. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.854 |
Rmag_0446 | leuD | Rmag_0446 | Rmag_0371 | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: dar:Daro_3074 acetolactate synthase, small subunit. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.852 |
Rmag_0458 | Rmag_0066 | Rmag_0458 | Rmag_0066 | 2-oxo-acid dehydrogenase E1 subunit, homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | PFAM: pyruvate kinase; KEGG: vpa:VP2039 pyruvate kinase II; Belongs to the pyruvate kinase family. | 0.913 |
Rmag_0458 | Rmag_0446 | Rmag_0458 | Rmag_0446 | 2-oxo-acid dehydrogenase E1 subunit, homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: dar:Daro_3074 acetolactate synthase, small subunit. | 0.804 |