node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
hisA | hisB | Rmag_0977 | Rmag_0950 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: sde:Sde_0489 response regulator receiver domain protein (CheY-like); TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: bpm:BURPS1710b_3691 imidazoleglycerol-phosphate dehydratase. | 0.955 |
hisA | hisD | Rmag_0977 | Rmag_0602 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: sde:Sde_0489 response regulator receiver domain protein (CheY-like); TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.972 |
hisA | hisE | Rmag_0977 | Rmag_0288 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: sde:Sde_0489 response regulator receiver domain protein (CheY-like); TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis. | PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: tbd:Tbd_1706 phosphoribosyl-ATP pyrophosphohydrolase. | 0.948 |
hisA | hisF | Rmag_0977 | Rmag_0028 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: sde:Sde_0489 response regulator receiver domain protein (CheY-like); TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.994 |
hisA | hisG | Rmag_0977 | Rmag_0601 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: sde:Sde_0489 response regulator receiver domain protein (CheY-like); TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis. | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.949 |
hisA | hisH | Rmag_0977 | Rmag_0949 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: sde:Sde_0489 response regulator receiver domain protein (CheY-like); TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.997 |
hisA | hisI | Rmag_0977 | Rmag_0289 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: sde:Sde_0489 response regulator receiver domain protein (CheY-like); TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.999 |
hisA | hisS | Rmag_0977 | Rmag_0671 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: sde:Sde_0489 response regulator receiver domain protein (CheY-like); TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis. | KEGG: ppu:PP0854 histidyl-tRNA synthetase; TIGRFAM: histidyl-tRNA synthetase; PFAM: tRNA synthetase, class II (G, H, P and S); Anticodon-binding domain protein. | 0.438 |
hisA | hisZ | Rmag_0977 | Rmag_0532 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: sde:Sde_0489 response regulator receiver domain protein (CheY-like); TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis. | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.861 |
hisB | hisA | Rmag_0950 | Rmag_0977 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: bpm:BURPS1710b_3691 imidazoleglycerol-phosphate dehydratase. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: sde:Sde_0489 response regulator receiver domain protein (CheY-like); TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis. | 0.955 |
hisB | hisD | Rmag_0950 | Rmag_0602 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: bpm:BURPS1710b_3691 imidazoleglycerol-phosphate dehydratase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.998 |
hisB | hisE | Rmag_0950 | Rmag_0288 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: bpm:BURPS1710b_3691 imidazoleglycerol-phosphate dehydratase. | PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: tbd:Tbd_1706 phosphoribosyl-ATP pyrophosphohydrolase. | 0.941 |
hisB | hisF | Rmag_0950 | Rmag_0028 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: bpm:BURPS1710b_3691 imidazoleglycerol-phosphate dehydratase. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.996 |
hisB | hisG | Rmag_0950 | Rmag_0601 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: bpm:BURPS1710b_3691 imidazoleglycerol-phosphate dehydratase. | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.962 |
hisB | hisH | Rmag_0950 | Rmag_0949 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: bpm:BURPS1710b_3691 imidazoleglycerol-phosphate dehydratase. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisB | hisI | Rmag_0950 | Rmag_0289 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: bpm:BURPS1710b_3691 imidazoleglycerol-phosphate dehydratase. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.975 |
hisB | hisZ | Rmag_0950 | Rmag_0532 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: bpm:BURPS1710b_3691 imidazoleglycerol-phosphate dehydratase. | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.873 |
hisD | hisA | Rmag_0602 | Rmag_0977 | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: sde:Sde_0489 response regulator receiver domain protein (CheY-like); TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis. | 0.972 |
hisD | hisB | Rmag_0602 | Rmag_0950 | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: bpm:BURPS1710b_3691 imidazoleglycerol-phosphate dehydratase. | 0.998 |
hisD | hisE | Rmag_0602 | Rmag_0288 | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: tbd:Tbd_1706 phosphoribosyl-ATP pyrophosphohydrolase. | 0.939 |