node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rmag_0308 | Rmag_0670 | Rmag_0308 | Rmag_0670 | PFAM: CMP/dCMP deaminase, zinc-binding; KEGG: xcb:XC_0132 deoxycytidylate deaminase. | PFAM: 5-nucleotidase; KEGG: noc:Noc_1810 5-nucleotidase. | 0.900 |
Rmag_0308 | surE | Rmag_0308 | Rmag_0910 | PFAM: CMP/dCMP deaminase, zinc-binding; KEGG: xcb:XC_0132 deoxycytidylate deaminase. | 5'-nucleotidase / 3'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.900 |
Rmag_0308 | thyA | Rmag_0308 | Rmag_0616 | PFAM: CMP/dCMP deaminase, zinc-binding; KEGG: xcb:XC_0132 deoxycytidylate deaminase. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.931 |
Rmag_0308 | tmk | Rmag_0308 | Rmag_0220 | PFAM: CMP/dCMP deaminase, zinc-binding; KEGG: xcb:XC_0132 deoxycytidylate deaminase. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.924 |
Rmag_0670 | Rmag_0308 | Rmag_0670 | Rmag_0308 | PFAM: 5-nucleotidase; KEGG: noc:Noc_1810 5-nucleotidase. | PFAM: CMP/dCMP deaminase, zinc-binding; KEGG: xcb:XC_0132 deoxycytidylate deaminase. | 0.900 |
Rmag_0670 | surE | Rmag_0670 | Rmag_0910 | PFAM: 5-nucleotidase; KEGG: noc:Noc_1810 5-nucleotidase. | 5'-nucleotidase / 3'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.900 |
Rmag_0670 | thyA | Rmag_0670 | Rmag_0616 | PFAM: 5-nucleotidase; KEGG: noc:Noc_1810 5-nucleotidase. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.900 |
Rmag_0670 | tmk | Rmag_0670 | Rmag_0220 | PFAM: 5-nucleotidase; KEGG: noc:Noc_1810 5-nucleotidase. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.900 |
Rmag_0851 | folD | Rmag_0851 | Rmag_0840 | KEGG: reu:Reut_A0215 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.941 |
Rmag_0851 | gcvT | Rmag_0851 | Rmag_0924 | KEGG: reu:Reut_A0215 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.942 |
Rmag_0851 | glyA | Rmag_0851 | Rmag_0632 | KEGG: reu:Reut_A0215 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.948 |
Rmag_0851 | thyA | Rmag_0851 | Rmag_0616 | KEGG: reu:Reut_A0215 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.935 |
Rmag_0999 | Rmag_1019 | Rmag_0999 | Rmag_1019 | FolC bifunctional protein; KEGG: mca:MCA2492 folylpolyglutamate synthase/dihydrofolate synthase; TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase, middle domain protein. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.935 |
Rmag_0999 | folD | Rmag_0999 | Rmag_0840 | FolC bifunctional protein; KEGG: mca:MCA2492 folylpolyglutamate synthase/dihydrofolate synthase; TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase, middle domain protein. | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.545 |
Rmag_0999 | glyA | Rmag_0999 | Rmag_0632 | FolC bifunctional protein; KEGG: mca:MCA2492 folylpolyglutamate synthase/dihydrofolate synthase; TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase, middle domain protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.724 |
Rmag_0999 | thyA | Rmag_0999 | Rmag_0616 | FolC bifunctional protein; KEGG: mca:MCA2492 folylpolyglutamate synthase/dihydrofolate synthase; TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase, middle domain protein. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.871 |
Rmag_1019 | Rmag_0999 | Rmag_1019 | Rmag_0999 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | FolC bifunctional protein; KEGG: mca:MCA2492 folylpolyglutamate synthase/dihydrofolate synthase; TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase, middle domain protein. | 0.935 |
Rmag_1019 | folD | Rmag_1019 | Rmag_0840 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.405 |
Rmag_1019 | gcvT | Rmag_1019 | Rmag_0924 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.916 |
Rmag_1019 | glyA | Rmag_1019 | Rmag_0632 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.941 |