| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Rmag_0409 | Rmag_0853 | Rmag_0409 | Rmag_0853 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: tcx:Tcr_0154 porphobilinogen synthase; Belongs to the ALAD family. | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.828 |
| Rmag_0409 | cysG | Rmag_0409 | Rmag_0270 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: tcx:Tcr_0154 porphobilinogen synthase; Belongs to the ALAD family. | uroporphyrinogen-III C-methyltransferase / precorrin-2 dehydrogenase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.810 |
| Rmag_0409 | hemA | Rmag_0409 | Rmag_0730 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: tcx:Tcr_0154 porphobilinogen synthase; Belongs to the ALAD family. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.844 |
| Rmag_0409 | hemC | Rmag_0409 | Rmag_0783 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: tcx:Tcr_0154 porphobilinogen synthase; Belongs to the ALAD family. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.995 |
| Rmag_0409 | hemE | Rmag_0409 | Rmag_1026 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: tcx:Tcr_0154 porphobilinogen synthase; Belongs to the ALAD family. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.706 |
| Rmag_0409 | hemH | Rmag_0409 | Rmag_0522 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: tcx:Tcr_0154 porphobilinogen synthase; Belongs to the ALAD family. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.541 |
| Rmag_0852 | Rmag_0853 | Rmag_0852 | Rmag_0853 | Hypothetical protein. | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.697 |
| Rmag_0852 | Rmag_0854 | Rmag_0852 | Rmag_0854 | Hypothetical protein. | Hypothetical protein. | 0.651 |
| Rmag_0852 | Rmag_0855 | Rmag_0852 | Rmag_0855 | Hypothetical protein. | TIGRFAM: Na+/Ca+ antiporter, CaCA family; PFAM: sodium/calcium exchanger membrane region; KEGG: tcx:Tcr_0977 K+-dependent Na+/Ca+ exchanger related-protein. | 0.479 |
| Rmag_0852 | Rmag_0856 | Rmag_0852 | Rmag_0856 | Hypothetical protein. | PFAM: protein of unknown function UPF0079; KEGG: msu:MS1514 predicted ATPase or kinase. | 0.584 |
| Rmag_0853 | Rmag_0409 | Rmag_0853 | Rmag_0409 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: tcx:Tcr_0154 porphobilinogen synthase; Belongs to the ALAD family. | 0.828 |
| Rmag_0853 | Rmag_0852 | Rmag_0853 | Rmag_0852 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Hypothetical protein. | 0.697 |
| Rmag_0853 | Rmag_0854 | Rmag_0853 | Rmag_0854 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Hypothetical protein. | 0.773 |
| Rmag_0853 | Rmag_0855 | Rmag_0853 | Rmag_0855 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | TIGRFAM: Na+/Ca+ antiporter, CaCA family; PFAM: sodium/calcium exchanger membrane region; KEGG: tcx:Tcr_0977 K+-dependent Na+/Ca+ exchanger related-protein. | 0.558 |
| Rmag_0853 | Rmag_0856 | Rmag_0853 | Rmag_0856 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | PFAM: protein of unknown function UPF0079; KEGG: msu:MS1514 predicted ATPase or kinase. | 0.558 |
| Rmag_0853 | cysG | Rmag_0853 | Rmag_0270 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | uroporphyrinogen-III C-methyltransferase / precorrin-2 dehydrogenase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.970 |
| Rmag_0853 | hemA | Rmag_0853 | Rmag_0730 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.635 |
| Rmag_0853 | hemC | Rmag_0853 | Rmag_0783 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.992 |
| Rmag_0853 | hemE | Rmag_0853 | Rmag_1026 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.950 |
| Rmag_0853 | hemH | Rmag_0853 | Rmag_0522 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.535 |
