node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rmag_0018 | Rmag_0769 | Rmag_0018 | Rmag_0769 | PFAM: homoserine O-succinyltransferase; KEGG: noc:Noc_2703 hypothetical protein. | PFAM: homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase, NAD-binding; KEGG: mca:MCA0597 homoserine dehydrogenase. | 0.929 |
Rmag_0018 | Rmag_0851 | Rmag_0018 | Rmag_0851 | PFAM: homoserine O-succinyltransferase; KEGG: noc:Noc_2703 hypothetical protein. | KEGG: reu:Reut_A0215 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.823 |
Rmag_0018 | glyA | Rmag_0018 | Rmag_0632 | PFAM: homoserine O-succinyltransferase; KEGG: noc:Noc_2703 hypothetical protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.800 |
Rmag_0018 | metE | Rmag_0018 | Rmag_0985 | PFAM: homoserine O-succinyltransferase; KEGG: noc:Noc_2703 hypothetical protein. | Methionine synthase (B12-independent); Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.567 |
Rmag_0018 | metK | Rmag_0018 | Rmag_0738 | PFAM: homoserine O-succinyltransferase; KEGG: noc:Noc_2703 hypothetical protein. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.458 |
Rmag_0018 | metZ | Rmag_0018 | Rmag_1002 | PFAM: homoserine O-succinyltransferase; KEGG: noc:Noc_2703 hypothetical protein. | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.966 |
Rmag_0739 | Rmag_0769 | Rmag_0739 | Rmag_0769 | KEGG: hch:HCH_01532 adenosylhomocysteinase; TIGRFAM: adenosylhomocysteinase; PFAM: S-adenosyl-L-homocysteine hydrolase. | PFAM: homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase, NAD-binding; KEGG: mca:MCA0597 homoserine dehydrogenase. | 0.811 |
Rmag_0739 | Rmag_0851 | Rmag_0739 | Rmag_0851 | KEGG: hch:HCH_01532 adenosylhomocysteinase; TIGRFAM: adenosylhomocysteinase; PFAM: S-adenosyl-L-homocysteine hydrolase. | KEGG: reu:Reut_A0215 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.472 |
Rmag_0739 | glyA | Rmag_0739 | Rmag_0632 | KEGG: hch:HCH_01532 adenosylhomocysteinase; TIGRFAM: adenosylhomocysteinase; PFAM: S-adenosyl-L-homocysteine hydrolase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.545 |
Rmag_0739 | metE | Rmag_0739 | Rmag_0985 | KEGG: hch:HCH_01532 adenosylhomocysteinase; TIGRFAM: adenosylhomocysteinase; PFAM: S-adenosyl-L-homocysteine hydrolase. | Methionine synthase (B12-independent); Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.970 |
Rmag_0739 | metK | Rmag_0739 | Rmag_0738 | KEGG: hch:HCH_01532 adenosylhomocysteinase; TIGRFAM: adenosylhomocysteinase; PFAM: S-adenosyl-L-homocysteine hydrolase. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.875 |
Rmag_0739 | metZ | Rmag_0739 | Rmag_1002 | KEGG: hch:HCH_01532 adenosylhomocysteinase; TIGRFAM: adenosylhomocysteinase; PFAM: S-adenosyl-L-homocysteine hydrolase. | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.940 |
Rmag_0769 | Rmag_0018 | Rmag_0769 | Rmag_0018 | PFAM: homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase, NAD-binding; KEGG: mca:MCA0597 homoserine dehydrogenase. | PFAM: homoserine O-succinyltransferase; KEGG: noc:Noc_2703 hypothetical protein. | 0.929 |
Rmag_0769 | Rmag_0739 | Rmag_0769 | Rmag_0739 | PFAM: homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase, NAD-binding; KEGG: mca:MCA0597 homoserine dehydrogenase. | KEGG: hch:HCH_01532 adenosylhomocysteinase; TIGRFAM: adenosylhomocysteinase; PFAM: S-adenosyl-L-homocysteine hydrolase. | 0.811 |
Rmag_0769 | Rmag_0851 | Rmag_0769 | Rmag_0851 | PFAM: homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase, NAD-binding; KEGG: mca:MCA0597 homoserine dehydrogenase. | KEGG: reu:Reut_A0215 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.469 |
Rmag_0769 | metE | Rmag_0769 | Rmag_0985 | PFAM: homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase, NAD-binding; KEGG: mca:MCA0597 homoserine dehydrogenase. | Methionine synthase (B12-independent); Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.867 |
Rmag_0769 | metZ | Rmag_0769 | Rmag_1002 | PFAM: homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase, NAD-binding; KEGG: mca:MCA0597 homoserine dehydrogenase. | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.921 |
Rmag_0851 | Rmag_0018 | Rmag_0851 | Rmag_0018 | KEGG: reu:Reut_A0215 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | PFAM: homoserine O-succinyltransferase; KEGG: noc:Noc_2703 hypothetical protein. | 0.823 |
Rmag_0851 | Rmag_0739 | Rmag_0851 | Rmag_0739 | KEGG: reu:Reut_A0215 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | KEGG: hch:HCH_01532 adenosylhomocysteinase; TIGRFAM: adenosylhomocysteinase; PFAM: S-adenosyl-L-homocysteine hydrolase. | 0.472 |
Rmag_0851 | Rmag_0769 | Rmag_0851 | Rmag_0769 | KEGG: reu:Reut_A0215 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | PFAM: homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase, NAD-binding; KEGG: mca:MCA0597 homoserine dehydrogenase. | 0.469 |