Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
abrBSimilar to Bacillus subtilis transition state regulatory protein AbrB or CpsX or bsu00370 SWALL:ABRB_BACSU (SWALL:P08874) (96 aa) fasta scores: E(): 1.4e-12, 74.19 38d in 62 aa, and to Clostridium acetobutylicum transition state regulatory protein AbrB cac3647 SWALL:Q97D34 (EMBL:AE007860) (81 aa) fasta scores: E(): 1.2e-26, 90.12 38d in 81 aa. (81 aa)    
Predicted Functional Partners:
spo0A
Stage 0 sporulation protein A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.
  
   
 0.906
sigH
RNA polymerase sigma-H factor; Belongs to the sigma-70 factor family.
  
   
 0.767
spoIIAB
Anti-sigma F factor; Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.
  
  
 0.714
spoIIID
Similar to Bacillus subtilis stage III sporulation protein D SpoIIID or bsu36420 SWALL:SP3D_BACSU (SWALL:P15281) (93 aa) fasta scores: E(): 1.1e-16, 62.65 id in 83 aa, and to Clostridium acetobutylicum stage iii sporulation protein D SpoIIID cac2859 SWALL:Q97F82 (EMBL:AE007783) (84 aa) fasta scores: E(): 9e-24, 89.28 id in 84 aa.
  
   
 0.707
spoIVA
Stage IV sporulation protein A; ATPase. Has a role at an early stage in the morphogenesis of the spore coat.
  
   
 0.685
spoIIIAC
Stage III sporulation protein AC.
  
   
 0.620
gerAA
Spore germination protein.
  
   
 0.609
codY
GTP-sensing transcriptional pleiotropic repressor CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family.
  
   
 0.596
gerAA-2
Spore germination protein.
  
   
 0.594
spoIIR
Similar to Bacillus subtilis stage II sporulation protein R SpoIIR or Ipc-27d or bsu36970 SWALL:SP2R_BACSU (SWALL:P39151) (224 aa) fasta scores: E(): 1.9e-18, 35.71 id in 224 aa, and to Clostridium perfringens stage II sporulation protein R SpoIIR or cpe2211 SWALL:Q8XIB0 (EMBL:AP003193) (209 aa) fasta scores: E(): 1.5e-37,55.34 38d in 206 aa.
  
   
 0.586
Your Current Organism:
Clostridium botulinum A ATCC 3502
NCBI taxonomy Id: 413999
Other names: C. botulinum A str. ATCC 3502, Clostridium botulinum A str. ATCC 3502, Clostridium botulinum A strain ATCC 3502
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