Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
CBO0073Putative uracil-DNA glycosylase; Similar to Clostridium tetani DNA polymerase,bacteriophage-type ctc00242 SWALL:Q899E0 (EMBL:AE015936) (188 aa) fasta scores: E(): 1e-52, 63.97 38d in 186 aa,and to Thermoanaerobacter tengcongensis uracil-DNA glycosylase tte0077 SWALL:Q8RDF7 (EMBL:AE012981) (186 aa) fasta scores: E(): 4.2e-42, 56.21 38d in 185 aa. (190 aa)    
Predicted Functional Partners:
CBO0042A
Uracyl DNA glycosilase; Similar to Clostridium acetobutylicum uracyl DNA glycosilase cac0219 SWALL:Q97MH9 (EMBL:AE007535) (199 aa) fasta scores: E(): 5.7e-53, 67 38d in 197 aa, and to Clostridium tetani DNA polymerase, bacteriophage-type ctc00062 SWALL:Q899V2 (EMBL:AE015936) (173 aa) fasta scores: E(): 8.9e-41, 64.88 38d in 168 aa.
 
  
 
0.936
CBO0074
MarR-family transcriptional regulator; Similar to Bacillus subtilis organic hydroperoxide resistance transcriptional regulator OhrR or bsu13150 SWALL:OHRR_BACSU (SWALL:O34777) (147 aa) fasta scores: E(): 0.00012, 27.27 38d in 143 aa, and to Staphylococcus aureus hypothetical protein sav2386 or sa2174 SWALL:Q99RP3 (EMBL:AP003365) (148 aa) fasta scores: E(): 1.4e-05,28.87 38d in 142 aa.
       0.693
yeaZ
Putative peptidase.
  
    0.577
CBO0072
Putative Na+ driven multidrug efflux pump; Similar to Vibrio parahaemolyticus multidrug resistance protein NorM or vp1479 SWALL:NORM_VIBPA (SWALL:O82855) (456 aa) fasta scores: E(): 8.1e-23, 26.57 id in 414 aa, and to Clostridium tetani Na+ driven multidrug efflux pump ctc01799 SWALL:Q893L8 (EMBL:AE015942) (455 aa) fasta scores: E(): 6.5e-93,52.71 38d in 442 aa.
       0.560
metG
methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
     
 0.476
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
     
 0.451
topB
Putative DNA topoisomerase; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing D [...]
  
    0.450
nnrE
Putative carbohydrate kinase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of [...]
  
    0.414
Your Current Organism:
Clostridium botulinum A ATCC 3502
NCBI taxonomy Id: 413999
Other names: C. botulinum A str. ATCC 3502, Clostridium botulinum A str. ATCC 3502, Clostridium botulinum A strain ATCC 3502
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