Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-expression
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[Homology]
Score
CBO0098Conserved hypothetical protein; Similar to Clostridium acetobutylicum Zn-dependent hydrolases of the metallo-beta-lactamase superfamily cac0482 SWALL:Q97LS2 (EMBL:AE007563) (211 aa) fasta scores: E(): 2e-35, 44.07 38d in 211 aa, and to Thermoanaerobacter tengcongensis predicted Zn-dependent hydrolases of the beta-lactamase fold tte2532 SWALL:Q8R787 (EMBL:AE013195) (212 aa) fasta scores: E(): 1.4e-31, 44.5 id in 200 aa. (212 aa)    
Predicted Functional Partners:
CBO0097
Similar to Clostridium acetobutylicum predicted transcriptional regulator cap0153 SWALL:Q97TF1 (EMBL:AE001438) (115 aa) fasta scores: E(): 2.3e-29,73.45 38d in 113 aa, and to Clostridium tetani putative transcriptional regulator PadR or ctc00601 SWALL:Q897X0 (EMBL:AE015938) (106 aa) fasta scores: E(): 3.6e-20,52.88 38d in 104 aa.
     
 0.652
CBO0096
Putative membrane protein; Similar to Clostridium acetobutylicum membrane protein cap0154 SWALL:Q97TF0 (EMBL:AE001438) (225 aa) fasta scores: E(): 3.1e-26, 39.64 38d in 222 aa, and to Bacillus cereus hypothetical protein bc4207 SWALL:Q818P2 (EMBL:AE017011) (226 aa) fasta scores: E(): 4.2e-06,24.31 38d in 218 aa.
     
 0.644
psd2
Phosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
   
   0.556
ileS
isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
  
    0.535
CBO0348
Similar to Clostridium acetobutylicum hypothetical protein Cac0449 SWALL:Q97LV5 (EMBL:AE007559) (156 aa) fasta scores: E(): 1.5e-29, 56.66 38d in 150 aa.
   
    0.501
CBO2587
Putative AMP-binding enzyme; Similar to an internal region of Bacillus licheniformis bacitracin synthetase 1 BacA SWALL:BACA_BACLI (SWALL:O68006) (5255 aa) fasta scores: E(): 4.3e-49, 33.15 38d in 561 aa.
  
  
 0.420
ribA
3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
       0.410
ribD
Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
       0.410
nnrE
Putative carbohydrate kinase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of [...]
       0.410
Your Current Organism:
Clostridium botulinum A ATCC 3502
NCBI taxonomy Id: 413999
Other names: C. botulinum A str. ATCC 3502, Clostridium botulinum A str. ATCC 3502, Clostridium botulinum A strain ATCC 3502
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