STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
rpiBSimilar to Escherichia coli ribose 5-phosphate isomerase B RpiB or b4090 SWALL:RPIB_ECOLI (SWALL:P37351) (149 aa) fasta scores: E(): 2.2e-27, 52.77 38d in 144 aa,and to Clostridium tetani ribose 5-phosphate isomerase ctc00307 SWALL:Q898Y0 (EMBL:AE015936) (149 aa) fasta scores: E(): 1.5e-43, 78.47 38d in 144 aa. (145 aa)    
Predicted Functional Partners:
upp
Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate.
 
    0.974
rpe
Putative ribulose-phosphate 3-epimerase; Similar to the C-terminal region of Solanum tuberosum ribulose-phosphate 3-epimerase, chloroplast precursor SWALL:RPE_SOLTU (SWALL:Q43843) (280 aa) fasta scores: E(): 1.7e-34, 51.4 38d in 214 aa.
  
 
 0.951
CBO0143
Similar to Acinetobacter johnsonii low molecular weight protein-tyrosine-phosphatase Ptp SWALL:PTP_ACIJO (SWALL:O52787) (142 aa) fasta scores: E(): 4.2e-06, 33.59 id in 128 aa, and to Clostridium tetani phosphotyrosine protein phosphatase ctc00306 SWALL:Q898Y1 (EMBL:AE015936) (154 aa) fasta scores: E(): 1.9e-24, 54.05 38d in 148 aa.
      0.950
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
 
  
 0.943
prsA
Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
  
 
 0.939
tkt
Transketolase, pyridine binding subunit; Similar to C-terminal region of several transketolases including Homo sapiens transketolase Tkt or Tkt1 SWALL:TKT_HUMAN (SWALL:P29401) (623 aa) fasta scores: E(): 6e-37, 40.69 38d in 317 aa.
    
 0.919
rbsK
Ribokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
    
 0.917
tkt-2
Transketolase, thiamine disphosphate-bindin subunit; Similar to the N-terminal region of several transketolase including Homo sapiens transketolase Tkt or Tkt1 SWALL:TKT_HUMAN (SWALL:P29401) (623 aa) fasta scores: E(): 3.8e-36, 42.85 38d in 273 aa.
    
 0.916
pgcA
Alpha-phosphoglucomutase.
     
 0.906
CBO3619
Putative phosphoglucomutase/phosphomannomutase.
     
 0.906
Your Current Organism:
Clostridium botulinum A ATCC 3502
NCBI taxonomy Id: 413999
Other names: C. botulinum A str. ATCC 3502, Clostridium botulinum A str. ATCC 3502, Clostridium botulinum A strain ATCC 3502
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.