Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (213 aa)    
Predicted Functional Partners:
exoA
Putative exodeoxyribonuclease.
 
 0.975
hup
DNA-binding protein HU; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.
 
   
 0.744
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
 
 
 0.734
CBO2764
Putative endonuclease.
  
 
 0.705
rnfE
Electron transport complex protein; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
 
  
 0.683
plsD
Probable acyltransferase; Similar to Clostridium butyricum sn-glycerol-3-phosphate acyltransferase plsD SWALL:O32330 (EMBL:AF009362) (234 aa) fasta scores: E(): 9e-45, 56.65 id in 233 aa.
  
    0.661
rnfG
Electron transport complex protein; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the RnfG family.
  
  
 0.612
mutL
DNA mismatch repair protein; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
  
 
 0.548
CBO0210
NAD-dependent malic enzyme; Similar to Bacillus stearothermophilus NAD-dependent malic enzyme SWALL:MAOX_BACST (SWALL:P16468) (478 aa) fasta scores: E(): 7e-79, 59.38 38d in 389 aa,and to Clostridium tetani NAD-dependent malic enzyme ctc00356 SWALL:Q898T6 (EMBL:AE015937) (389 aa) fasta scores: E(): 6.1e-102, 73.52 38d in 389 aa; Also similar to CBO0246 (66.6 38d).
       0.520
queG
Similar to Clostridium tetani iron-sulfur cluster-binding protein ctc00352 SWALL:Q898T9 (EMBL:AE015937) (327 aa) fasta scores: E(): 2.3e-75,61.12 38d in 319 aa.
       0.507
Your Current Organism:
Clostridium botulinum A ATCC 3502
NCBI taxonomy Id: 413999
Other names: C. botulinum A str. ATCC 3502, Clostridium botulinum A str. ATCC 3502, Clostridium botulinum A strain ATCC 3502
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