Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
CBO0256Putative exonuclease; Similar to Clostridium acetobutylicum DNA polymerase III epsilon subunit cac0738 SWALL:Q97L28 (EMBL:AE007589) (306 aa) fasta scores: E(): 7.7e-76,68.75 38d in 304 aa. (309 aa)    
Predicted Functional Partners:
dnaE
DNA polymerase III alpha subunit.
   
 0.974
dnaN
DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...]
   
 0.965
holA
Conserved hypothetical protein.
  
 
 0.952
dnaX
DNA polymerase III subunit gamma/tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
   
 0.951
CBO0056
Similar to Escherichia coli DNA polymerase III,delta' subunit HolB or b1099 SWALL:HOLB_ECOLI (SWALL:P28631) (334 aa) fasta scores: E(): 1.3e-05, 22.05 id in 263 aa, and to Clostridium tetani DNA polymerase III delta subunit ctc00221 SWALL:Q899F8 (EMBL:AE015936) (322 aa) fasta scores: E(): 1.1e-52, 53.35 38d in 313 aa.
   
 0.951
polC
DNA polymerase III PolC-type; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
    
0.910
CBO0910
Putative serine peptidase; Similar over its C-terminal region to several LexA repressors including Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri lexa repressor SWALL:LEXA_ECOLI (SWALL:P03033) (202 aa) fasta scores: E(): 2.5e-07, 31.78 38d in 129 aa; Belongs to the peptidase S24 family.
 
  
 0.697
CBO0255
Putative reductase; Similar to Thermotoga maritima dihydrofolate reductase FolA or DyrA or tm1641 SWALL:DYR_THEMA (SWALL:Q60034) (169 aa) fasta scores: E(): 0.00064, 24.56 id in 171 aa, and to Bacillus cereus pyrimidine reductase bc0650 SWALL:Q813Y8 (EMBL:AE017000) (173 aa) fasta scores: E(): 1.8e-16, 37.19 38d in 164 aa.
 
     0.639
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
  
  
 0.568
CBO0254
Putative acetyltransferase; Similar to Listeria innocua hypothetical protein Lin2361 SWALL:Q929B6 (EMBL:AL596172) (291 aa) fasta scores: E(): 3.5e-39, 37.75 38d in 294 aa, and to Bacillus halodurans hypothetical protein Bh3929 bh3929 SWALL:Q9K606 (EMBL:AP001520) (286 aa) fasta scores: E(): 1.7e-23,30.47 38d in 292 aa.
       0.526
Your Current Organism:
Clostridium botulinum A ATCC 3502
NCBI taxonomy Id: 413999
Other names: C. botulinum A str. ATCC 3502, Clostridium botulinum A str. ATCC 3502, Clostridium botulinum A strain ATCC 3502
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