Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
CBO0417Putative 2-isopropylmalate synthase; Similar to Streptomyces hygroscopicus 2-phosphinomethylmalic acid synthase PmmS SWALL:Q9LCB4 (EMBL:AB029822) (440 aa) fasta scores: E(): 3.5e-55,38.53 38d in 436 aa, and to Salmonella typhimurium 2-isopropylmalate synthase LeuA or stm0113 SWALL:LEU1_SALTY (SWALL:P15875) (522 aa) fasta scores: E(): 7.1e-10, 25.91 38d in 355 aa. (452 aa)    
Predicted Functional Partners:
CBO0419
Similar to Coccidioides immitis isocitrate dehydrogenase IcdH SWALL:Q8X1D0 (EMBL:AF439265) (347 aa) fasta scores: E(): 2e-58, 51.35 38d in 333 aa.
 
 
 0.969
nifJ1
Putative pyruvate-flavodoxin oxidoreductase; Also similar to CBO2760 (65.74 38d).
  
 
 0.961
nifJ2
Pyruvate-flavodoxin oxidoreductase; Also similar to CBO1192 (65.74 38d).
  
 
 0.959
accC
Biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
  
 
 0.938
pyc
Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.
  
 
 0.931
acoC
Dihydrolipoamide acetyltransferase component of acetoin dehydrogenase complex.
    
 0.923
CBO3422
Putative subunit of pyruvate:flavodoxin oxidoreductase.
   
 
 0.910
CBO3423
Putative subunit of pyruvate:flavodoxin oxidoreductase.
   
 
 0.910
thl
acetyl-CoA acetyltransferase (thiolase); Belongs to the thiolase-like superfamily. Thiolase family.
  
 
 0.894
CBO2756
Putative aminotransferase; Possible alternative translational start site.
  
 
 0.874
Your Current Organism:
Clostridium botulinum A ATCC 3502
NCBI taxonomy Id: 413999
Other names: C. botulinum A str. ATCC 3502, Clostridium botulinum A str. ATCC 3502, Clostridium botulinum A strain ATCC 3502
Server load: medium (42%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.