CBO0727 protein (Clostridium botulinum A ATCC 3502)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

CBO0727

Conserved hypothetical protein. (208 aa)

Predicted Functional Partners:

cysK

0.707

luxS

0.680

metC

0.599

ispA

0.588

nifJ1

0.471

birA

0.410

Your Current Organism:

Clostridium botulinum A ATCC 3502

NCBI taxonomy Id: 413999
Other names: C. botulinum A str. ATCC 3502, Clostridium botulinum A str. ATCC 3502, Clostridium botulinum A strain ATCC 3502

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBO0727	birA	CBO0727	CBO1117	Conserved hypothetical protein.	BirA bifunctional protein [includes: biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.	0.410
CBO0727	cysK	CBO0727	CBO0724	Conserved hypothetical protein.	Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family.	0.707
CBO0727	ispA	CBO0727	CBO1883	Conserved hypothetical protein.	Geranyltranstransferase; Belongs to the FPP/GGPP synthase family.	0.588
CBO0727	luxS	CBO0727	CBO0725	Conserved hypothetical protein.	S-ribosylhomocysteinase; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family.	0.680
CBO0727	metC	CBO0727	CBO0726	Conserved hypothetical protein.	Cystathionine beta-lyase.	0.599
CBO0727	nifJ1	CBO0727	CBO1192	Conserved hypothetical protein.	Putative pyruvate-flavodoxin oxidoreductase; Also similar to CBO2760 (65.74 38d).	0.471
birA	CBO0727	CBO1117	CBO0727	BirA bifunctional protein [includes: biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.	Conserved hypothetical protein.	0.410
cysK	CBO0727	CBO0724	CBO0727	Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family.	Conserved hypothetical protein.	0.707
cysK	luxS	CBO0724	CBO0725	Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family.	S-ribosylhomocysteinase; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family.	0.973
cysK	metC	CBO0724	CBO0726	Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family.	Cystathionine beta-lyase.	0.994
ispA	CBO0727	CBO1883	CBO0727	Geranyltranstransferase; Belongs to the FPP/GGPP synthase family.	Conserved hypothetical protein.	0.588
luxS	CBO0727	CBO0725	CBO0727	S-ribosylhomocysteinase; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family.	Conserved hypothetical protein.	0.680
luxS	cysK	CBO0725	CBO0724	S-ribosylhomocysteinase; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family.	Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family.	0.973
luxS	metC	CBO0725	CBO0726	S-ribosylhomocysteinase; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family.	Cystathionine beta-lyase.	0.994
metC	CBO0727	CBO0726	CBO0727	Cystathionine beta-lyase.	Conserved hypothetical protein.	0.599
metC	cysK	CBO0726	CBO0724	Cystathionine beta-lyase.	Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family.	0.994
metC	luxS	CBO0726	CBO0725	Cystathionine beta-lyase.	S-ribosylhomocysteinase; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family.	0.994
nifJ1	CBO0727	CBO1192	CBO0727	Putative pyruvate-flavodoxin oxidoreductase; Also similar to CBO2760 (65.74 38d).	Conserved hypothetical protein.	0.471