STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
botRRNA polymerase ECF-type sigma factor; Previously sequenced as Clostridium botulinum hypothetical protein p-21 or botR SWALL:Q57176 (EMBL:X79104) (178 aa) fasta scores: E(): 9.6e-61, 100 38d in 178 aa. (178 aa)    
Predicted Functional Partners:
ha33
Hemagglutinin component of the neurotoxin complex; Previously sequenced in Clostridium botulinum as Ha-33 protein Ha-33 or Ha33 SWALL:Q45871 (EMBL:X79104) (293 aa) fasta scores: E(): 4.2e-113, 100 38d in 293 aa.
     
 0.825
ntnH
Previously sequenced in Clostridium botulinum as type A progenitor toxin nontoxic-nonha Ant or NtnH SWALL:Q45914 (EMBL:D67030) (1193 aa) fasta scores: E(): 0,100 38d in 1193 aa.
     
 0.822
ha17
Hemagglutinin component of the neurotoxin complex; Previously sequenced in Clostridium as botulinum Ha17 or Ha-17 SWALL:Q45878 (EMBL:L42537) (146 aa) fasta scores: E(): 4e-58, 100 38d in 146 aa.
     
 0.792
ha70
Putative transposase (partial); Predicted helix-turn-helix motif with score 1032.000, SD 2.70 at aa 23-44, sequence VSFGVLAQECNINKQDIQKCFV.
     
 0.789
codY
GTP-sensing transcriptional pleiotropic repressor CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family.
      
 0.725
uviB
Bacteriocin UviB precursor.
     
 0.661
botA
Similar to Clostridium botulinum botulinum neurotoxin type A precursor BotA or Bna or Atx SWALL:BXA1_CLOBO (SWALL:P10845) (1295 aa) fasta scores: E(): 0, 99.92 38d in 1295 aa.
     
 0.643
rpoB
DNA-directed RNA polymerase beta chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.641
CBO0787
Two component sensor kinase.
      
 0.609
CBO3437
Putative lipoprotein; No significant database matches.
  
 
 0.540
Your Current Organism:
Clostridium botulinum A ATCC 3502
NCBI taxonomy Id: 413999
Other names: C. botulinum A str. ATCC 3502, Clostridium botulinum A str. ATCC 3502, Clostridium botulinum A strain ATCC 3502
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