STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
botRRNA polymerase ECF-type sigma factor; Previously sequenced as Clostridium botulinum hypothetical protein p-21 or botR SWALL:Q57176 (EMBL:X79104) (178 aa) fasta scores: E(): 9.6e-61, 100 38d in 178 aa. (178 aa)    
Predicted Functional Partners:
ha33
Hemagglutinin component of the neurotoxin complex; Previously sequenced in Clostridium botulinum as Ha-33 protein Ha-33 or Ha33 SWALL:Q45871 (EMBL:X79104) (293 aa) fasta scores: E(): 4.2e-113, 100 38d in 293 aa.
     
 0.803
ntnH
Previously sequenced in Clostridium botulinum as type A progenitor toxin nontoxic-nonha Ant or NtnH SWALL:Q45914 (EMBL:D67030) (1193 aa) fasta scores: E(): 0,100 38d in 1193 aa.
     
 0.801
ha17
Hemagglutinin component of the neurotoxin complex; Previously sequenced in Clostridium as botulinum Ha17 or Ha-17 SWALL:Q45878 (EMBL:L42537) (146 aa) fasta scores: E(): 4e-58, 100 38d in 146 aa.
     
 0.767
ha70
Putative transposase (partial); Predicted helix-turn-helix motif with score 1032.000, SD 2.70 at aa 23-44, sequence VSFGVLAQECNINKQDIQKCFV.
     
 0.764
uviB
Bacteriocin UviB precursor.
     
 0.674
codY
GTP-sensing transcriptional pleiotropic repressor CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family.
      
 0.640
botA
Similar to Clostridium botulinum botulinum neurotoxin type A precursor BotA or Bna or Atx SWALL:BXA1_CLOBO (SWALL:P10845) (1295 aa) fasta scores: E(): 0, 99.92 38d in 1295 aa.
     
 0.614
rpoB
DNA-directed RNA polymerase beta chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.584
CBO0786
Two component response regulator.
      
 0.540
CBO0787
Two component sensor kinase.
      
 0.537
Your Current Organism:
Clostridium botulinum A ATCC 3502
NCBI taxonomy Id: 413999
Other names: C. botulinum A str. ATCC 3502, Clostridium botulinum A str. ATCC 3502, Clostridium botulinum A strain ATCC 3502
Server load: medium (54%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.