Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
folK2-amino-4-hydroxy-6- hydroxymethyldihydropteridinepyrophosphokinase. (151 aa)    
Predicted Functional Partners:
folP
Dihydropteroate synthase.
 
 0.999
folE
Putative GTP cyclohydrolase I.
  
 0.999
folC
Putative folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family.
  
 0.936
CBO0522
Putative metallo-beta-lactamase family protein.
     
  0.900
CBO1062
Metallo-beta-lactamase superfamily protein.
     
  0.900
CBO2288
Metallo-beta-lactamase superfamily protein.
     
  0.900
ribA
3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
  
  
 0.754
aroF
Putative 2-dehydro-3-deoxyphosphooctonate aldolase.
   
 0.738
rdgB
Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
  
  
 0.699
queD-2
Conserved hypothetical protein.
     
 0.698
Your Current Organism:
Clostridium botulinum A ATCC 3502
NCBI taxonomy Id: 413999
Other names: C. botulinum A str. ATCC 3502, Clostridium botulinum A str. ATCC 3502, Clostridium botulinum A strain ATCC 3502
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