| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| act | cobB | CBO3215 | CBO0924 | Formate-lyase activating enzyme; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family. | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.434 |
| act | cobU | CBO3215 | CBO0911 | Formate-lyase activating enzyme; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family. | Bifunctional cobalamin biosynthesis protein [includes: cobinamide kinase; cobinamide phosphate guanylyltransferase]. | 0.789 |
| cbiB | cbiF | CBO0915 | CBO0947 | Cobalamin biosynthesis protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | Precorrin-4 C11-methyltransferase. | 0.862 |
| cbiB | cbiH | CBO0915 | CBO0949 | Cobalamin biosynthesis protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | Precorrin-3b C17-methyltransferase. | 0.869 |
| cbiB | cbiL | CBO0915 | CBO0946 | Cobalamin biosynthesis protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | Precorrin-2 C20-methyltransferase; Methylates cobalt-precorrin-2 at the C-20 position to produce cobalt-precorrin-3A in the anaerobic cobalamin biosynthesis pathway. | 0.844 |
| cbiB | cobA | CBO0915 | CBO0954 | Cobalamin biosynthesis protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | cob(I)alamin adenosyltransferase. | 0.975 |
| cbiB | cobB | CBO0915 | CBO0924 | Cobalamin biosynthesis protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.923 |
| cbiB | cobH | CBO0915 | CBO0925 | Cobalamin biosynthesis protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | Precorrin-8x methylmutase. | 0.902 |
| cbiB | cobQ | CBO0915 | CBO0914 | Cobalamin biosynthesis protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.997 |
| cbiB | cobS | CBO0915 | CBO0821 | Cobalamin biosynthesis protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | Cobalamin synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.869 |
| cbiB | cobU | CBO0915 | CBO0911 | Cobalamin biosynthesis protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | Bifunctional cobalamin biosynthesis protein [includes: cobinamide kinase; cobinamide phosphate guanylyltransferase]. | 0.986 |
| cbiF | cbiB | CBO0947 | CBO0915 | Precorrin-4 C11-methyltransferase. | Cobalamin biosynthesis protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.862 |
| cbiF | cbiH | CBO0947 | CBO0949 | Precorrin-4 C11-methyltransferase. | Precorrin-3b C17-methyltransferase. | 0.997 |
| cbiF | cbiL | CBO0947 | CBO0946 | Precorrin-4 C11-methyltransferase. | Precorrin-2 C20-methyltransferase; Methylates cobalt-precorrin-2 at the C-20 position to produce cobalt-precorrin-3A in the anaerobic cobalamin biosynthesis pathway. | 0.983 |
| cbiF | cobA | CBO0947 | CBO0954 | Precorrin-4 C11-methyltransferase. | cob(I)alamin adenosyltransferase. | 0.582 |
| cbiF | cobB | CBO0947 | CBO0924 | Precorrin-4 C11-methyltransferase. | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.933 |
| cbiF | cobH | CBO0947 | CBO0925 | Precorrin-4 C11-methyltransferase. | Precorrin-8x methylmutase. | 0.993 |
| cbiF | cobQ | CBO0947 | CBO0914 | Precorrin-4 C11-methyltransferase. | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.987 |
| cbiF | cobS | CBO0947 | CBO0821 | Precorrin-4 C11-methyltransferase. | Cobalamin synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.841 |
| cbiF | cobU | CBO0947 | CBO0911 | Precorrin-4 C11-methyltransferase. | Bifunctional cobalamin biosynthesis protein [includes: cobinamide kinase; cobinamide phosphate guanylyltransferase]. | 0.791 |