Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
hupLHydrogenase large subunit; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (471 aa)    
Predicted Functional Partners:
hupS
Hydrogenase small subunit.
 
 0.999
hupD
Putative hydrogenase maturation protein.
 
 
 0.958
CBO1332
Putative oxidoreductase, electron transfer subunit.
  
 
 0.928
hypD
Hydrogenase isoenzymes formation protein.
 
 
 0.918
hypF
Hydrogenase maturation protein.
 
 
 
 0.907
cooS
Putative oxidoreductase, acetyl-CoA synthase subunit.
    
 0.901
cooS-2
Putative carbon monoxide dehydrogenase beta subunit.
    
 0.901
hypA-2
Putative hydrogenase nickel incorporation protein; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
 
 
 0.884
hypE
Hydrogenase isoenzymes formation protein.
 
   
 0.880
hypB-2
Similar to the C-terminal region of Escherichia coli, and Escherichia coli O6 hydrogenase isoenzymes nickel incorporation protein HypB or b2727 or c3287 SWALL:HYPB_ECOLI (SWALL:P24190) (290 aa) fasta scores: E(): 3e-25, 42.99 38d in 207 aa. Similar to the full length Thermoanaerobacter tengcongensis Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase TTE0130 SWALL:Q8RDB1 (EMBL:AE012986) (218 aa) fasta scores: E(): 5.2e-25,44.66 38d in 206 aa.
 
  
 0.784
Your Current Organism:
Clostridium botulinum A ATCC 3502
NCBI taxonomy Id: 413999
Other names: C. botulinum A str. ATCC 3502, Clostridium botulinum A str. ATCC 3502, Clostridium botulinum A strain ATCC 3502
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