Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Score
spo0AStage 0 sporulation protein A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. (273 aa)    
Predicted Functional Partners:
spoIIE
Putative stage II sporulation protein.
  
  
 0.945
spoIIAB
Anti-sigma F factor; Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.
 
  
 0.942
spoIVB
Stage IV sporulation protein B.
   
 0.937
spoIIID
Similar to Bacillus subtilis stage III sporulation protein D SpoIIID or bsu36420 SWALL:SP3D_BACSU (SWALL:P15281) (93 aa) fasta scores: E(): 1.1e-16, 62.65 id in 83 aa, and to Clostridium acetobutylicum stage iii sporulation protein D SpoIIID cac2859 SWALL:Q97F82 (EMBL:AE007783) (84 aa) fasta scores: E(): 9e-24, 89.28 id in 84 aa.
  
   
 0.926
sigF
RNA polymerase sigma-F factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
  
  
 0.908
abrB
Similar to Bacillus subtilis transition state regulatory protein AbrB or CpsX or bsu00370 SWALL:ABRB_BACSU (SWALL:P08874) (96 aa) fasta scores: E(): 1.4e-12, 74.19 38d in 62 aa, and to Clostridium acetobutylicum transition state regulatory protein AbrB cac3647 SWALL:Q97D34 (EMBL:AE007860) (81 aa) fasta scores: E(): 1.2e-26, 90.12 38d in 81 aa.
  
   
 0.906
spoIVA
Stage IV sporulation protein A; ATPase. Has a role at an early stage in the morphogenesis of the spore coat.
  
   
 0.901
sigK
RNA polymerase sigma-28 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
  
  
 0.901
spoIIR
Similar to Bacillus subtilis stage II sporulation protein R SpoIIR or Ipc-27d or bsu36970 SWALL:SP2R_BACSU (SWALL:P39151) (224 aa) fasta scores: E(): 1.9e-18, 35.71 id in 224 aa, and to Clostridium perfringens stage II sporulation protein R SpoIIR or cpe2211 SWALL:Q8XIB0 (EMBL:AP003193) (209 aa) fasta scores: E(): 1.5e-37,55.34 38d in 206 aa.
  
   
 0.895
abrB-2
SpoVT/AbrB family regulatory protein.
  
   
 0.890
Your Current Organism:
Clostridium botulinum A ATCC 3502
NCBI taxonomy Id: 413999
Other names: C. botulinum A str. ATCC 3502, Clostridium botulinum A str. ATCC 3502, Clostridium botulinum A strain ATCC 3502
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