STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hadAisocaprenoyl-CoA:2-hydroxyisocaproate CoA-transferase; This gene from C. difficile was cloned,overexpressed in E. coli, and characterized as 2-hydroxyisocaproate CoA-transferase, a class III enzyme (Kim et al. 2004. FEMS Microbiol. Rev. 28, 455-468); Belongs to the CoA-transferase III family. (404 aa)    
Predicted Functional Partners:
hadB
Subunit of oxygen-sensitive 2-hydroxyisocaproyl-CoA dehydratase; Similar to Acidaminococcus fermentans (R)-2-hydroxyglutaryl-CoA dehydratase alpha-subunit HgdA SWALL:HGDA_ACIFE (SWALL:P11569) (476 aa) fasta scores: E(): 1e-53, 39.91 38d in 471 aa. CDS contains internal deletion in comparison to the A. fermentans protein. Full length CDS is similar to Clostridium sporogenes r-phenyllactate dehydratase medium subunit FldB SWALL:Q93AL9 (EMBL:AF420489) (407 aa) fasta scores: E(): 1.7e-84, 51.47 38d in 408 aa.
 
   
 0.893
hadC
Subunit of oxygen-sensitive 2-hydroxyisocaproyl-CoA dehydratase.
 
   
 0.879
CBO2193
Putative membrane protein; CDS is extended at the C-terminus in comparison to similar proteins. N-terminal region is similar to Pyrococcus horikoshii hypothetical protein PH0137 SWALL:O57877 (EMBL:AP000001) (378 aa) fasta scores: E(): 6.4e-17, 26.5 38d in 381 aa.
 
     0.778
fldB
R-phenyllactate dehydratase medium subunit.
 
   
 0.737
CBO3285
Conserved membrane protein.
 
     0.702
fldC
R-phenyllactate dehydratase small subunit.
 
   
 0.690
hisF
Imidazole glycerol phosphate synthase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
      
 0.640
acdB
acyl-CoA dehydrogenase, short-chain specific.
 
 0.618
aspC
Aspartate aminotransferase.
      
 0.533
aspC-2
Aspartate aminotransferase.
      
 0.533
Your Current Organism:
Clostridium botulinum A ATCC 3502
NCBI taxonomy Id: 413999
Other names: C. botulinum A str. ATCC 3502, Clostridium botulinum A str. ATCC 3502, Clostridium botulinum A strain ATCC 3502
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