Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
CBO2216Putative exported protein; No significant database matches to the full length CDS. N-terminal region is similar to Clostridium tetani conserved protein CTC01609 SWALL:Q894D9 (EMBL:AE015941) (307 aa) fasta scores: E(): 3.3e-70, 62.58 38d in 310 aa. C-terminal region is similar to Bacteroides thetaiotaomicron hypothetical protein BT2193 SWALL:Q8A5P5 (EMBL:AE016935) (557 aa) fasta scores: E(): 1.3e-47,32.73 38d in 498 aa. Possible bifunctional protein. (820 aa)    
Predicted Functional Partners:
lepA
GTP-binding protein; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner.
    
  0.671
CBO2505
Putative protein phosphatase.
   
 
 0.654
CBO0570
Putative protease.
  
     0.581
cobB-2
Putative regulatory protein; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class U subfamily.
   
 
 0.579
CBO2215
Conserved hypothetical protein.
 
     0.563
CBO2602
Putative malate/lactate dehydrogenase; Weakly similar to many L-lactate dehydrogenases. Possible alternative translational start sites downstream of the current one.
  
 
 
 0.543
ldh
L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate.
    
 
 0.482
glpK
Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate.
    
 0.458
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
    
 
 0.454
CBO1025
Putative protease I.
    
   0.442
Your Current Organism:
Clostridium botulinum A ATCC 3502
NCBI taxonomy Id: 413999
Other names: C. botulinum A str. ATCC 3502, Clostridium botulinum A str. ATCC 3502, Clostridium botulinum A strain ATCC 3502
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