STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hypB-2Similar to the C-terminal region of Escherichia coli, and Escherichia coli O6 hydrogenase isoenzymes nickel incorporation protein HypB or b2727 or c3287 SWALL:HYPB_ECOLI (SWALL:P24190) (290 aa) fasta scores: E(): 3e-25, 42.99 38d in 207 aa. Similar to the full length Thermoanaerobacter tengcongensis Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase TTE0130 SWALL:Q8RDB1 (EMBL:AE012986) (218 aa) fasta scores: E(): 5.2e-25,44.66 38d in 206 aa. (212 aa)    
Predicted Functional Partners:
hypA-2
Putative hydrogenase nickel incorporation protein; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
 
 
 0.979
hypD
Hydrogenase isoenzymes formation protein.
 
  
 0.922
hypA
Similar to Bradyrhizobium japonicum hydrogenase nickel incorporation protein HypA or bll6932 SWALL:HYPA_BRAJA (SWALL:Q45256) (113 aa) fasta scores: E(): 6.6e-08, 30 38d in 110 aa.
 
 
 0.903
hypF
Hydrogenase maturation protein.
 
   
 0.853
hypE
Hydrogenase isoenzymes formation protein.
 
  
 0.847
hupS
Hydrogenase small subunit.
 
  
 0.795
hupL
Hydrogenase large subunit; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
 
  
 0.793
bioD
Putative dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring.
   
  
 0.693
fesA
Putative ferredoxin.
  
  
 0.653
hemB
Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
      
 0.641
Your Current Organism:
Clostridium botulinum A ATCC 3502
NCBI taxonomy Id: 413999
Other names: C. botulinum A str. ATCC 3502, Clostridium botulinum A str. ATCC 3502, Clostridium botulinum A strain ATCC 3502
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