Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
CBO2254Putative membrane protein; Similar to Enterococcus faecalis hypothetical protein EF2778 SWALL:Q830K3 (EMBL:AE016955) (176 aa) fasta scores: E(): 1.1e-25, 46.62 38d in 178 aa, and to Streptococcus pneumoniae conserved domain protein SP0723 SWALL:Q97RS0 (EMBL:AE007380) (174 aa) fasta scores: E(): 1.1e-22, 44.57 38d in 166 aa. CDS is extended at the C-terminus in comparison to orthologues. CDS feature contains an long overlap with the downstream CDS (CBO2253). Possible frameshift mutation after codon 158. (189 aa)    
Predicted Functional Partners:
thiM-2
Conserved hypothetical protein (partial); Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family.
 
     0.901
thiE
Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
 
     0.548
thiM
Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family.
 
     0.486
CBO2550
Puative phage RecT protein; Also similar to N-terminal region of CBO0479 (82.8 id).
  
     0.467
nifJ1
Putative pyruvate-flavodoxin oxidoreductase; Also similar to CBO2760 (65.74 38d).
       0.410
nifJ2
Pyruvate-flavodoxin oxidoreductase; Also similar to CBO1192 (65.74 38d).
       0.410
Your Current Organism:
Clostridium botulinum A ATCC 3502
NCBI taxonomy Id: 413999
Other names: C. botulinum A str. ATCC 3502, Clostridium botulinum A str. ATCC 3502, Clostridium botulinum A strain ATCC 3502
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