bioD protein (Clostridium botulinum A ATCC 3502)

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bioD

Putative dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (227 aa)

Predicted Functional Partners:

bioB-2

0.999

bioB

0.986

CBO2260

0.883

birA

0.794

hypB

0.729

hypB-2

0.729

nadC

0.640

cobS

0.595

panC

0.580

cobA

0.577

Your Current Organism:

Clostridium botulinum A ATCC 3502

NCBI taxonomy Id: 413999
Other names: C. botulinum A str. ATCC 3502, Clostridium botulinum A str. ATCC 3502, Clostridium botulinum A strain ATCC 3502

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBO2260	bioB	CBO2260	CBO3582	BioY family protein.	Biotin synthase.	0.402
CBO2260	bioB-2	CBO2260	CBO2259	BioY family protein.	Putative biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.	0.862
CBO2260	bioD	CBO2260	CBO2258	BioY family protein.	Putative dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring.	0.883
CBO2260	birA	CBO2260	CBO1117	BioY family protein.	BirA bifunctional protein [includes: biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.	0.757
bioB	CBO2260	CBO3582	CBO2260	Biotin synthase.	BioY family protein.	0.402
bioB	bioB-2	CBO3582	CBO2259	Biotin synthase.	Putative biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.	0.908
bioB	bioD	CBO3582	CBO2258	Biotin synthase.	Putative dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring.	0.986
bioB	birA	CBO3582	CBO1117	Biotin synthase.	BirA bifunctional protein [includes: biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.	0.965
bioB-2	CBO2260	CBO2259	CBO2260	Putative biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.	BioY family protein.	0.862
bioB-2	bioB	CBO2259	CBO3582	Putative biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.	Biotin synthase.	0.908
bioB-2	bioD	CBO2259	CBO2258	Putative biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.	Putative dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring.	0.999
bioB-2	birA	CBO2259	CBO1117	Putative biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.	BirA bifunctional protein [includes: biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.	0.965
bioD	CBO2260	CBO2258	CBO2260	Putative dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring.	BioY family protein.	0.883
bioD	bioB	CBO2258	CBO3582	Putative dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring.	Biotin synthase.	0.986
bioD	bioB-2	CBO2258	CBO2259	Putative dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring.	Putative biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.	0.999
bioD	birA	CBO2258	CBO1117	Putative dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring.	BirA bifunctional protein [includes: biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.	0.794
bioD	cobA	CBO2258	CBO0954	Putative dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring.	cob(I)alamin adenosyltransferase.	0.577
bioD	cobS	CBO2258	CBO0821	Putative dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring.	Cobalamin synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family.	0.595
bioD	hypB	CBO2258	CBO0431	Putative dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring.	Hydrogenase nickel incorporation protein; Similar to Escherichia coli, and Escherichia coli O6 hydrogenase isoenzymes nickel incorporation protein HypB or b2727 or c3287 SWALL:HYPB_ECOLI (SWALL:P24190) (290 aa) fasta scores: E(): 3e-28, 40.74 38d in 216 aa.	0.729
bioD	hypB-2	CBO2258	CBO2220	Putative dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring.	Similar to the C-terminal region of Escherichia coli, and Escherichia coli O6 hydrogenase isoenzymes nickel incorporation protein HypB or b2727 or c3287 SWALL:HYPB_ECOLI (SWALL:P24190) (290 aa) fasta scores: E(): 3e-25, 42.99 38d in 207 aa. Similar to the full length Thermoanaerobacter tengcongensis Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase TTE0130 SWALL:Q8RDB1 (EMBL:AE012986) (218 aa) fasta scores: E(): 5.2e-25,44.66 38d in 206 aa.	0.729

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