STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
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[Homology]
Score
msrBPutative methionine sulfoxide reductase; Similar to the C-terminal region of Streptococcus pneumoniae, and Streptococcus pneumoniae peptide methionine sulfoxide reductase MsrA/MsrB 2 MsrAB2 or msrA or sp0660 or spr0577 SWALL:MAB2_STRPN (SWALL:Q97RX3) (311 aa) fasta scores: E(): 6.1e-34, 63.12 38d in 141 aa, and to the full length Clostridium perfringens peptide methionine sulfoxide reductase CPE1607 SWALL:MSRB_CLOPE (SWALL:Q8XJZ6) (147 aa) fasta scores: E(): 2.4e-49, 84.13 id in 145 aa. (149 aa)    
Predicted Functional Partners:
msrA
Peptide methionine sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
 
 0.996
CBO1391
Putative peptide methionine sulfoxide reductase.
 
 0.982
ccdA2
Cytochrome C-type biogenesis protein.
   
 
 0.804
CBO2765
Conserved hypothetical protein.
   
 0.803
grpE
Heat shock protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depen [...]
   
 
 0.713
CBO0183
Putative pyridine nucleotide-disulphide oxidoreductase; Similar to Fusobacterium nucleatum coenzyme a disulfide reductase/ disulfide bond regulator domain fn1903 SWALL:Q8RHU1 (EMBL:AE010492) (810 aa) fasta scores: E(): 1e-163, 56.35 38d in 818 aa, and to Fusobacterium nucleatum subsp. vincentii ATCC 49256 coenzyme a disulfide reductase/ disulfide bond regulator domain fnv2089 SWALL:Q7P7P1 (EMBL:AABF01000012) (809 aa) fasta scores: E(): 2.7e-159, 55.5 38d in 818 aa; Belongs to the sulfur carrier protein TusA family.
  
  
 0.703
hslO
Chaperonin; Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.
      
 0.571
rpmJ
50S ribosomal protein L36; Belongs to the bacterial ribosomal protein bL36 family.
    
 
 0.543
opuCB
Glycine betaine/carnitine/choline transport system permease protein opucb.
 
  
 0.540
CBO2277
Putative superoxide dismutase [Mn/Fe]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.
  
  
 0.529
Your Current Organism:
Clostridium botulinum A ATCC 3502
NCBI taxonomy Id: 413999
Other names: C. botulinum A str. ATCC 3502, Clostridium botulinum A str. ATCC 3502, Clostridium botulinum A strain ATCC 3502
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