Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
CBO2293Short chain dehydrogenase; C-terminal region is similar to Bacillus megaterium glucose 1-dehydrogenase III GdhIII SWALL:DHG3_BACME (SWALL:P39484) (261 aa) fasta scores: E(): 2.9e-23, 34.41 id in 247 aa. Full length CDS is similar to Clostridium acetobutylicum predicted dehydrogenase of short-chain alcohol dehydrogenase family, ortholog of YhdF B.subtilis CAC1423 SWALL:Q97J63 (EMBL:AE007653) (299 aa) fasta scores: E(): 1.8e-76, 68.7 38d in 294 aa. (299 aa)    
Predicted Functional Partners:
CBO2587
Putative AMP-binding enzyme; Similar to an internal region of Bacillus licheniformis bacitracin synthetase 1 BacA SWALL:BACA_BACLI (SWALL:O68006) (5255 aa) fasta scores: E(): 4.3e-49, 33.15 38d in 561 aa.
  
 
 0.666
CBO1505
Putative oxidoreductase.
 
 0.649
cypC
Fatty acid beta-hydroxylating cytochrome P450.
  
 
 0.593
thl
acetyl-CoA acetyltransferase (thiolase); Belongs to the thiolase-like superfamily. Thiolase family.
  
 
 0.549
sbcD
Nuclease subunit D; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family.
   
 
 0.531
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
   
 
 0.520
ppiB
Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.
   
 
 0.492
fabF
3-oxoacyl-[acyl-carrier-protein] synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.
  
 
 0.467
CBO1525
Conserved hypothetical protein.
  
     0.437
fabD
Malonyl CoA-acyl carrier protein transacylase.
  
 
 0.431
Your Current Organism:
Clostridium botulinum A ATCC 3502
NCBI taxonomy Id: 413999
Other names: C. botulinum A str. ATCC 3502, Clostridium botulinum A str. ATCC 3502, Clostridium botulinum A strain ATCC 3502
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.