Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
CBO2376N-terminal region is similar to Bacillus subtilis RNA polymerase sigma-E factor precursor SigE or SpoIIGB or BSU15320 SWALL:RPSE_BACSU (SWALL:P06222) (239 aa) fasta scores: E(): 7.1e-08, 32.95 38d in 176 aa. (317 aa)    
Predicted Functional Partners:
spoIIAB
Anti-sigma F factor; Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.
 
 
 0.915
abrB-2
SpoVT/AbrB family regulatory protein.
 
     0.865
flgM
Negative regulator of flagellin synthesis.
  
 
 0.783
CBO2375
Hypothetical phage protein; No significant database matches.
       0.773
spoIVA
Stage IV sporulation protein A; ATPase. Has a role at an early stage in the morphogenesis of the spore coat.
  
    0.760
spoIIAA
Anti-sigma F factor antagonist; Belongs to the anti-sigma-factor antagonist family.
 
  
 0.756
spoVAD
Stage V sporulation protein AD.
 
    0.751
spoVAC2
Stage V sporulation protein AC.
 
     0.746
spoVAC1
Stage V sporulation protein AC.
 
     0.741
CBO2373
Hypothetical phage protein.
       0.733
Your Current Organism:
Clostridium botulinum A ATCC 3502
NCBI taxonomy Id: 413999
Other names: C. botulinum A str. ATCC 3502, Clostridium botulinum A str. ATCC 3502, Clostridium botulinum A strain ATCC 3502
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