| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CBO0324 | ccpA | CBO0324 | CBO0100 | Putative membrane protein; Similar to Clostridium tetani conserved protein,putative murein hydrolase exporter ctc01825 SWALL:Q893J3 (EMBL:AE015942) (117 aa) fasta scores: E(): 1.9e-30,67.52 38d in 117 aa. | LacI-family transcriptional regulator (catabolite control protein); Similar to Clostridium saccharobutylicum hth-type transcriptional regulator RegA or RepA SWALL:REGA_CLOSA (SWALL:Q45831) (332 aa) fasta scores: E(): 1.2e-72, 65.75 id in 330 aa, and to Bacillus megaterium glucose-resistance amylase regulator CcpA SWALL:CCPA_BACME (SWALL:P46828) (332 aa) fasta scores: E(): 3.2e-45, 44.61 id in 334 aa. | 0.485 |
| CBO0324 | codY | CBO0324 | CBO2436 | Putative membrane protein; Similar to Clostridium tetani conserved protein,putative murein hydrolase exporter ctc01825 SWALL:Q893J3 (EMBL:AE015942) (117 aa) fasta scores: E(): 1.9e-30,67.52 38d in 117 aa. | GTP-sensing transcriptional pleiotropic repressor CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family. | 0.657 |
| abrB-2 | codY | CBO2374 | CBO2436 | SpoVT/AbrB family regulatory protein. | GTP-sensing transcriptional pleiotropic repressor CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family. | 0.610 |
| abrB-2 | sigH | CBO2374 | CBO3497 | SpoVT/AbrB family regulatory protein. | RNA polymerase sigma-H factor; Belongs to the sigma-70 factor family. | 0.762 |
| abrB-2 | spo0A | CBO2374 | CBO1872 | SpoVT/AbrB family regulatory protein. | Stage 0 sporulation protein A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. | 0.890 |
| botR | codY | CBO0804 | CBO2436 | RNA polymerase ECF-type sigma factor; Previously sequenced as Clostridium botulinum hypothetical protein p-21 or botR SWALL:Q57176 (EMBL:X79104) (178 aa) fasta scores: E(): 9.6e-61, 100 38d in 178 aa. | GTP-sensing transcriptional pleiotropic repressor CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family. | 0.725 |
| ccpA | CBO0324 | CBO0100 | CBO0324 | LacI-family transcriptional regulator (catabolite control protein); Similar to Clostridium saccharobutylicum hth-type transcriptional regulator RegA or RepA SWALL:REGA_CLOSA (SWALL:Q45831) (332 aa) fasta scores: E(): 1.2e-72, 65.75 id in 330 aa, and to Bacillus megaterium glucose-resistance amylase regulator CcpA SWALL:CCPA_BACME (SWALL:P46828) (332 aa) fasta scores: E(): 3.2e-45, 44.61 id in 334 aa. | Putative membrane protein; Similar to Clostridium tetani conserved protein,putative murein hydrolase exporter ctc01825 SWALL:Q893J3 (EMBL:AE015942) (117 aa) fasta scores: E(): 1.9e-30,67.52 38d in 117 aa. | 0.485 |
| ccpA | codY | CBO0100 | CBO2436 | LacI-family transcriptional regulator (catabolite control protein); Similar to Clostridium saccharobutylicum hth-type transcriptional regulator RegA or RepA SWALL:REGA_CLOSA (SWALL:Q45831) (332 aa) fasta scores: E(): 1.2e-72, 65.75 id in 330 aa, and to Bacillus megaterium glucose-resistance amylase regulator CcpA SWALL:CCPA_BACME (SWALL:P46828) (332 aa) fasta scores: E(): 3.2e-45, 44.61 id in 334 aa. | GTP-sensing transcriptional pleiotropic repressor CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family. | 0.851 |
| ccpA | hprK | CBO0100 | CBO2608 | LacI-family transcriptional regulator (catabolite control protein); Similar to Clostridium saccharobutylicum hth-type transcriptional regulator RegA or RepA SWALL:REGA_CLOSA (SWALL:Q45831) (332 aa) fasta scores: E(): 1.2e-72, 65.75 id in 330 aa, and to Bacillus megaterium glucose-resistance amylase regulator CcpA SWALL:CCPA_BACME (SWALL:P46828) (332 aa) fasta scores: E(): 3.2e-45, 44.61 id in 334 aa. | Putative HPr(Ser) kinase/phosphatase; Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metaboli [...] | 0.791 |
| ccpA | sigD | CBO0100 | CBO2641 | LacI-family transcriptional regulator (catabolite control protein); Similar to Clostridium saccharobutylicum hth-type transcriptional regulator RegA or RepA SWALL:REGA_CLOSA (SWALL:Q45831) (332 aa) fasta scores: E(): 1.2e-72, 65.75 id in 330 aa, and to Bacillus megaterium glucose-resistance amylase regulator CcpA SWALL:CCPA_BACME (SWALL:P46828) (332 aa) fasta scores: E(): 3.2e-45, 44.61 id in 334 aa. | RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. | 0.683 |
| ccpA | sigH | CBO0100 | CBO3497 | LacI-family transcriptional regulator (catabolite control protein); Similar to Clostridium saccharobutylicum hth-type transcriptional regulator RegA or RepA SWALL:REGA_CLOSA (SWALL:Q45831) (332 aa) fasta scores: E(): 1.2e-72, 65.75 id in 330 aa, and to Bacillus megaterium glucose-resistance amylase regulator CcpA SWALL:CCPA_BACME (SWALL:P46828) (332 aa) fasta scores: E(): 3.2e-45, 44.61 id in 334 aa. | RNA polymerase sigma-H factor; Belongs to the sigma-70 factor family. | 0.521 |
| ccpA | spo0A | CBO0100 | CBO1872 | LacI-family transcriptional regulator (catabolite control protein); Similar to Clostridium saccharobutylicum hth-type transcriptional regulator RegA or RepA SWALL:REGA_CLOSA (SWALL:Q45831) (332 aa) fasta scores: E(): 1.2e-72, 65.75 id in 330 aa, and to Bacillus megaterium glucose-resistance amylase regulator CcpA SWALL:CCPA_BACME (SWALL:P46828) (332 aa) fasta scores: E(): 3.2e-45, 44.61 id in 334 aa. | Stage 0 sporulation protein A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. | 0.785 |
| codY | CBO0324 | CBO2436 | CBO0324 | GTP-sensing transcriptional pleiotropic repressor CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family. | Putative membrane protein; Similar to Clostridium tetani conserved protein,putative murein hydrolase exporter ctc01825 SWALL:Q893J3 (EMBL:AE015942) (117 aa) fasta scores: E(): 1.9e-30,67.52 38d in 117 aa. | 0.657 |
| codY | abrB-2 | CBO2436 | CBO2374 | GTP-sensing transcriptional pleiotropic repressor CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family. | SpoVT/AbrB family regulatory protein. | 0.610 |
| codY | botR | CBO2436 | CBO0804 | GTP-sensing transcriptional pleiotropic repressor CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family. | RNA polymerase ECF-type sigma factor; Previously sequenced as Clostridium botulinum hypothetical protein p-21 or botR SWALL:Q57176 (EMBL:X79104) (178 aa) fasta scores: E(): 9.6e-61, 100 38d in 178 aa. | 0.725 |
| codY | ccpA | CBO2436 | CBO0100 | GTP-sensing transcriptional pleiotropic repressor CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family. | LacI-family transcriptional regulator (catabolite control protein); Similar to Clostridium saccharobutylicum hth-type transcriptional regulator RegA or RepA SWALL:REGA_CLOSA (SWALL:Q45831) (332 aa) fasta scores: E(): 1.2e-72, 65.75 id in 330 aa, and to Bacillus megaterium glucose-resistance amylase regulator CcpA SWALL:CCPA_BACME (SWALL:P46828) (332 aa) fasta scores: E(): 3.2e-45, 44.61 id in 334 aa. | 0.851 |
| codY | hprK | CBO2436 | CBO2608 | GTP-sensing transcriptional pleiotropic repressor CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family. | Putative HPr(Ser) kinase/phosphatase; Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metaboli [...] | 0.627 |
| codY | sepF | CBO2436 | CBO1466 | GTP-sensing transcriptional pleiotropic repressor CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family. | Conserved hypothetical protein; Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA. | 0.632 |
| codY | sigD | CBO2436 | CBO2641 | GTP-sensing transcriptional pleiotropic repressor CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family. | RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. | 0.822 |
| codY | sigH | CBO2436 | CBO3497 | GTP-sensing transcriptional pleiotropic repressor CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family. | RNA polymerase sigma-H factor; Belongs to the sigma-70 factor family. | 0.861 |