STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
topAPutative DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing [...] (696 aa)    
Predicted Functional Partners:
recQ
ATP-dependent DNA helicase.
 
 0.939
nifJ1
Putative pyruvate-flavodoxin oxidoreductase; Also similar to CBO2760 (65.74 38d).
  
   0.918
leuS
Similar to Escherichia coli leucyl-tRNA synthetase LeuS or b0642 SWALL:SYL_ECOLI (SWALL:P07813) (860 aa) fasta scores: E(): 4.7e-104, 40.67 38d in 858 aa, and to Clostridium tetani leucyl-tRNA synthetase LeuSor ctc00337 SWALL:SYL_CLOTE (SWALL:Q898V2) (812 aa) fasta scores: E(): 0, 76.26 38d in 813 aa; Belongs to the class-I aminoacyl-tRNA synthetase family.
   
 
 0.917
nifJ2
Pyruvate-flavodoxin oxidoreductase; Also similar to CBO1192 (65.74 38d).
  
   0.910
ssb
Single-strand binding protein; Similar to Clostridium acetobutylicum single-strand binding protein 1 Ssb1 or cac0945 SWALL:Q97KH4 (EMBL:AE007610) (110 aa) fasta scores: E(): 2.3e-17,47.66 38d in 107 aa.
  
 
 0.888
CBO3157
Single-stranded DNA binding protein.
  
 
 0.888
ssBb
Single-strand binding protein.
  
 
 0.888
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
 
 0.884
dprA
SMF family protein; C-terminus is similar to the C-terminal region of Haemophilus influenzae Smf protein HI0985 SWALL:SMF_HAEIN (SWALL:P43862) (373 aa) fasta scores: E(): 3e-26, 35.64 id in 317 aa, and to Clostridium tetani Smf protein,putative DNA processing chain A CTC01258 SWALL:Q895L5 (EMBL:AE015940) (361 aa) fasta scores: E(): 1.5e-65,54.69 38d in 362 aa.
   
 0.843
rpoA
DNA-directed RNA polymerase alpha chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
  
 
 0.843
Your Current Organism:
Clostridium botulinum A ATCC 3502
NCBI taxonomy Id: 413999
Other names: C. botulinum A str. ATCC 3502, Clostridium botulinum A str. ATCC 3502, Clostridium botulinum A strain ATCC 3502
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.