| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CBO2504 | hprK | CBO2504 | CBO2608 | Putative serine/threonine-protein kinase. | Putative HPr(Ser) kinase/phosphatase; Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metaboli [...] | 0.518 |
| CBO2607 | CBO2609 | CBO2607 | CBO2609 | 5-formyltetrahydrofolate cyclo-ligase family protein; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Conserved hypothetical protein. | 0.754 |
| CBO2607 | hprK | CBO2607 | CBO2608 | 5-formyltetrahydrofolate cyclo-ligase family protein; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Putative HPr(Ser) kinase/phosphatase; Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metaboli [...] | 0.828 |
| CBO2609 | CBO2607 | CBO2609 | CBO2607 | Conserved hypothetical protein. | 5-formyltetrahydrofolate cyclo-ligase family protein; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | 0.754 |
| CBO2609 | hprK | CBO2609 | CBO2608 | Conserved hypothetical protein. | Putative HPr(Ser) kinase/phosphatase; Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metaboli [...] | 0.754 |
| ccpA | codY | CBO0100 | CBO2436 | LacI-family transcriptional regulator (catabolite control protein); Similar to Clostridium saccharobutylicum hth-type transcriptional regulator RegA or RepA SWALL:REGA_CLOSA (SWALL:Q45831) (332 aa) fasta scores: E(): 1.2e-72, 65.75 id in 330 aa, and to Bacillus megaterium glucose-resistance amylase regulator CcpA SWALL:CCPA_BACME (SWALL:P46828) (332 aa) fasta scores: E(): 3.2e-45, 44.61 id in 334 aa. | GTP-sensing transcriptional pleiotropic repressor CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family. | 0.851 |
| ccpA | hprK | CBO0100 | CBO2608 | LacI-family transcriptional regulator (catabolite control protein); Similar to Clostridium saccharobutylicum hth-type transcriptional regulator RegA or RepA SWALL:REGA_CLOSA (SWALL:Q45831) (332 aa) fasta scores: E(): 1.2e-72, 65.75 id in 330 aa, and to Bacillus megaterium glucose-resistance amylase regulator CcpA SWALL:CCPA_BACME (SWALL:P46828) (332 aa) fasta scores: E(): 3.2e-45, 44.61 id in 334 aa. | Putative HPr(Ser) kinase/phosphatase; Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metaboli [...] | 0.791 |
| ccpA | ptsH | CBO0100 | CBO2398 | LacI-family transcriptional regulator (catabolite control protein); Similar to Clostridium saccharobutylicum hth-type transcriptional regulator RegA or RepA SWALL:REGA_CLOSA (SWALL:Q45831) (332 aa) fasta scores: E(): 1.2e-72, 65.75 id in 330 aa, and to Bacillus megaterium glucose-resistance amylase regulator CcpA SWALL:CCPA_BACME (SWALL:P46828) (332 aa) fasta scores: E(): 3.2e-45, 44.61 id in 334 aa. | Putative phosphocarrier protein HPr. | 0.855 |
| codY | ccpA | CBO2436 | CBO0100 | GTP-sensing transcriptional pleiotropic repressor CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family. | LacI-family transcriptional regulator (catabolite control protein); Similar to Clostridium saccharobutylicum hth-type transcriptional regulator RegA or RepA SWALL:REGA_CLOSA (SWALL:Q45831) (332 aa) fasta scores: E(): 1.2e-72, 65.75 id in 330 aa, and to Bacillus megaterium glucose-resistance amylase regulator CcpA SWALL:CCPA_BACME (SWALL:P46828) (332 aa) fasta scores: E(): 3.2e-45, 44.61 id in 334 aa. | 0.851 |
| codY | hprK | CBO2436 | CBO2608 | GTP-sensing transcriptional pleiotropic repressor CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family. | Putative HPr(Ser) kinase/phosphatase; Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metaboli [...] | 0.627 |
| hprK | CBO2504 | CBO2608 | CBO2504 | Putative HPr(Ser) kinase/phosphatase; Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metaboli [...] | Putative serine/threonine-protein kinase. | 0.518 |
| hprK | CBO2607 | CBO2608 | CBO2607 | Putative HPr(Ser) kinase/phosphatase; Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metaboli [...] | 5-formyltetrahydrofolate cyclo-ligase family protein; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | 0.828 |
| hprK | CBO2609 | CBO2608 | CBO2609 | Putative HPr(Ser) kinase/phosphatase; Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metaboli [...] | Conserved hypothetical protein. | 0.754 |
| hprK | ccpA | CBO2608 | CBO0100 | Putative HPr(Ser) kinase/phosphatase; Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metaboli [...] | LacI-family transcriptional regulator (catabolite control protein); Similar to Clostridium saccharobutylicum hth-type transcriptional regulator RegA or RepA SWALL:REGA_CLOSA (SWALL:Q45831) (332 aa) fasta scores: E(): 1.2e-72, 65.75 id in 330 aa, and to Bacillus megaterium glucose-resistance amylase regulator CcpA SWALL:CCPA_BACME (SWALL:P46828) (332 aa) fasta scores: E(): 3.2e-45, 44.61 id in 334 aa. | 0.791 |
| hprK | codY | CBO2608 | CBO2436 | Putative HPr(Ser) kinase/phosphatase; Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metaboli [...] | GTP-sensing transcriptional pleiotropic repressor CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family. | 0.627 |
| hprK | lgt | CBO2608 | CBO3209 | Putative HPr(Ser) kinase/phosphatase; Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metaboli [...] | Putative prolipoprotein diacylglyceryl transferase; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. | 0.695 |
| hprK | nifJ1 | CBO2608 | CBO1192 | Putative HPr(Ser) kinase/phosphatase; Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metaboli [...] | Putative pyruvate-flavodoxin oxidoreductase; Also similar to CBO2760 (65.74 38d). | 0.812 |
| hprK | nifJ2 | CBO2608 | CBO2760 | Putative HPr(Ser) kinase/phosphatase; Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metaboli [...] | Pyruvate-flavodoxin oxidoreductase; Also similar to CBO1192 (65.74 38d). | 0.723 |
| hprK | ptsH | CBO2608 | CBO2398 | Putative HPr(Ser) kinase/phosphatase; Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metaboli [...] | Putative phosphocarrier protein HPr. | 0.875 |
| hprK | ptsI | CBO2608 | CBO3438 | Putative HPr(Ser) kinase/phosphatase; Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metaboli [...] | Phosphoenolpyruvate-protein phosphotransferase; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). | 0.741 |
