Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
spoIIPPutative stage II sporulation protein P. (363 aa)    
Predicted Functional Partners:
spoIIR
Similar to Bacillus subtilis stage II sporulation protein R SpoIIR or Ipc-27d or bsu36970 SWALL:SP2R_BACSU (SWALL:P39151) (224 aa) fasta scores: E(): 1.9e-18, 35.71 id in 224 aa, and to Clostridium perfringens stage II sporulation protein R SpoIIR or cpe2211 SWALL:Q8XIB0 (EMBL:AP003193) (209 aa) fasta scores: E(): 1.5e-37,55.34 38d in 206 aa.
  
   
 0.944
spoIIAB
Anti-sigma F factor; Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.
  
   
 0.935
spoIIE
Putative stage II sporulation protein.
  
   
 0.922
spoIIGA
Putative sporulation sigma-E factor processing peptidase.
  
   
 0.915
gpr
Germination protease; Initiates the rapid degradation of small, acid-soluble proteins during spore germination; Belongs to the peptidase A25 family.
 
  
 0.914
spoIID
Similar to Bacillus subtilis stage ii sporulation protein D SpoIID or spoIIC or bsu36750 SWALL:SP2D_BACSU (SWALL:P07372) (343 aa) fasta scores: E(): 2.9e-17, 35.07 id in 345 aa, and to Clostridium tetani stage II sporulation protein D ctc00315 SWALL:Q898X2 (EMBL:AE015936) (376 aa) fasta scores: E(): 1.9e-56,48.17 38d in 357 aa.
  
  
 0.910
spoIIID
Similar to Bacillus subtilis stage III sporulation protein D SpoIIID or bsu36420 SWALL:SP3D_BACSU (SWALL:P15281) (93 aa) fasta scores: E(): 1.1e-16, 62.65 id in 83 aa, and to Clostridium acetobutylicum stage iii sporulation protein D SpoIIID cac2859 SWALL:Q97F82 (EMBL:AE007783) (84 aa) fasta scores: E(): 9e-24, 89.28 id in 84 aa.
  
  
 0.904
spoIIM
Putative stage II sporulation protein.
  
   
 0.903
spoIVA
Stage IV sporulation protein A; ATPase. Has a role at an early stage in the morphogenesis of the spore coat.
 
   
 0.895
spoIIIAA
Stage III sporulation protein AA.
  
   
 0.893
Your Current Organism:
Clostridium botulinum A ATCC 3502
NCBI taxonomy Id: 413999
Other names: C. botulinum A str. ATCC 3502, Clostridium botulinum A str. ATCC 3502, Clostridium botulinum A strain ATCC 3502
Server load: low (20%) [HD]