Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
relAGTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (723 aa)    
Predicted Functional Partners:
gmk
Putative guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
  
 
 0.933
CBO0185
Putative guanosine 3',5'-bis-pyrophosphate (ppGpp) synthesis/degradation protein; Similar to Clostridium tetani GTP pyrophosphokinase ctc00336 SWALL:Q898V3 (EMBL:AE015937) (262 aa) fasta scores: E(): 8.5e-70, 77.86 38d in 262 aa.
    
 0.932
rpsF
30S ribosomal protein S6; Binds together with S18 to 16S ribosomal RNA.
  
 
 
 0.916
nrdD
Similar to Escherichia coli anaerobic ribonucleoside-triphosphate reductase NrdD or b4238 SWALL:NRDD_ECOLI (SWALL:P28903) (712 aa) fasta scores: E(): 3.3e-50, 32.23 38d in 726 aa, and to Clostridium acetobutylicum oxygen-sensitive ribonucleoside-triphosphate reductase NrdD cac0480 SWALL:Q97LS4 (EMBL:AE007562) (702 aa) fasta scores: E(): 1.2e-139, 74.07 38d in 706 aa.
     
 0.907
nrdF
Ribonucleoside-diphosphate reductase beta chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family.
   
 
  0.903
nrdE
Ribonucleoside-diphosphate reductase 2 alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
   
 
  0.903
CBO0191
Putative adenylate cyclase; Similar to Clostridium acetobutylicum adenilate cyclase, class2 cac0650 SWALL:Q97LB2 (EMBL:AE007580) (180 aa) fasta scores: E(): 8.5e-37, 64.77 38d in 176 aa, and to Clostridium perfringens hypothetical protein Cpe1352 cpe1352 SWALL:Q8XKP2 (EMBL:AP003190) (187 aa) fasta scores: E(): 6.5e-36, 62.92 38d in 178 aa.
    
  0.900
ribA
3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
  
 
 0.855
rplJ
50S ribosomal protein L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family.
  
   0.850
rplM
50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.
  
 
 0.847
Your Current Organism:
Clostridium botulinum A ATCC 3502
NCBI taxonomy Id: 413999
Other names: C. botulinum A str. ATCC 3502, Clostridium botulinum A str. ATCC 3502, Clostridium botulinum A strain ATCC 3502
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