Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
CBO3186Conserved hypothetical protein; Similar to the C-terminal portion of predicted DNA ligases (CAE10810, DNLJ_BACSU). (242 aa)    
Predicted Functional Partners:
rsmB
Putative ribosomal RNA methyltransferase; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.
  
  
 0.844
CBO1321
Putative DNA helicase.
  
  
 0.727
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
 
   
 0.718
CBO2089
Putative DNA helicase.
 
  
 0.716
CBO3188
Conserved hypothetical protein.
       0.670
pcrA-2
ATP-dependent DNA helicase.
  
  
 0.664
CBO3187
Hypothetical protein.
       0.663
pcrA
ATP-dependent DNA helicase.
 
  
 0.661
CBO0910
Putative serine peptidase; Similar over its C-terminal region to several LexA repressors including Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri lexa repressor SWALL:LEXA_ECOLI (SWALL:P03033) (202 aa) fasta scores: E(): 2.5e-07, 31.78 38d in 129 aa; Belongs to the peptidase S24 family.
  
  
 0.653
topA
Putative DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing [...]
 
 
 
 0.648
Your Current Organism:
Clostridium botulinum A ATCC 3502
NCBI taxonomy Id: 413999
Other names: C. botulinum A str. ATCC 3502, Clostridium botulinum A str. ATCC 3502, Clostridium botulinum A strain ATCC 3502
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