STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pyrDDihydroorotate dehydrogenase, catalytic subunit; Catalyzes the conversion of dihydroorotate to orotate. (298 aa)    
Predicted Functional Partners:
pyrE
Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
 
 0.999
pyrK
Dihydroorotate dehydrogenase electron transfer subunit; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).
 
 0.999
pyrC
Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
 
 0.999
pyrB
Aspartate carbamoyltransferase catalytic chain; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
 
  
 0.991
asrB
Anaerobic sulfite reductase subunit B.
 
 
 0.976
pyrF
Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily.
 
  
 0.971
pyrK1
Putative dihydroorotate dehydrogenase electron transfer subunit; Also similar to CBO3305 (67.698 38d. in 291 aa overlap).
 
 
 0.898
pyrK2
Putative dihydroorotate dehydrogenase electron transfer subunit; Self match: 67.698 38dentity (67.9310ngapped) in 291 aa overlap with CBO1644.
 
 
 0.897
CBO2274
Putative ferredoxin; Similar to Clostridium acetobutylicum predicted flavodoxin oxidoreductase CAC1860 SWALL:Q97HZ6 (EMBL:AE007694) (328 aa) fasta scores: E(): 8.3e-70,54.87 38d in 328 aa. C-terminal region is weakly similar to Bacillus subtilis dihydroorotate dehydrogenase electron transfer subunit PyrK or PyrZ or BSU15530 SWALL:PYRK_BACSU (SWALL:P25983) (256 aa) fasta scores: E(): 1.4e-06, 24.47 id in 237 aa.
 
 
 0.855
pyrP
Putative uracil permease.
  
  
 0.854
Your Current Organism:
Clostridium botulinum A ATCC 3502
NCBI taxonomy Id: 413999
Other names: C. botulinum A str. ATCC 3502, Clostridium botulinum A str. ATCC 3502, Clostridium botulinum A strain ATCC 3502
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