Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
CBO32442-hydroxyacyl-CoA dehydratase beta-subunit; Also similar to CBO2197 (24.4 38d), CBO2202 (29.2 id), CBO3245 (37.9), CBO3289 (26.1 38d), CBO3629 (38.9 id). (419 aa)    
Predicted Functional Partners:
CBO3242
Activator of 2-hydroxyacyl-CoA dehydratase.
 
 0.913
CBO3243
Conserved hypothetical protein.
 
   
 0.817
fldI
R-phenyllactate dehydratase activator.
 
 0.749
hadI
Activator of 2-hydroxyisocaproyl-CoA dehydratase.
 
 0.728
CBO1553
Putative activator of 2-hydroxyacyl-CoA dehydratase.
 
 
 0.662
CBO2574
Conserved hypothetical protein; Belongs to the sulfur carrier protein TusA family.
 
    0.642
CBO2201
Putative 2-hydroxyacyl-CoA dehydratase,D-component.
 
 
 
 0.584
CBO3245
2-hydroxyacyl-CoA dehydratase beta-subunit; Also similar to CBO2197 (24.4 38d), CBO2202 (29.2 id), CBO3246 (37.9), CBO3289 (26.1 38d), CBO3629 (38.9 id).
 
    
0.566
hadB
Subunit of oxygen-sensitive 2-hydroxyisocaproyl-CoA dehydratase; Similar to Acidaminococcus fermentans (R)-2-hydroxyglutaryl-CoA dehydratase alpha-subunit HgdA SWALL:HGDA_ACIFE (SWALL:P11569) (476 aa) fasta scores: E(): 1e-53, 39.91 38d in 471 aa. CDS contains internal deletion in comparison to the A. fermentans protein. Full length CDS is similar to Clostridium sporogenes r-phenyllactate dehydratase medium subunit FldB SWALL:Q93AL9 (EMBL:AF420489) (407 aa) fasta scores: E(): 1.7e-84, 51.47 38d in 408 aa.
 
 
 
 0.527
CBO2202
Putative bifunctional protein [includes; Similar over its N-terminal region to small subunits of 2-hydroxyacyl-CoA dehydratases (hadC, HgdB and FldC), and over its C-terminal region to activators of 2-hydroxyacyl-CoA dehydratases (HadI, hgdC and FldI). Possible bifunctional fusion protein.
 
 
0.521
Your Current Organism:
Clostridium botulinum A ATCC 3502
NCBI taxonomy Id: 413999
Other names: C. botulinum A str. ATCC 3502, Clostridium botulinum A str. ATCC 3502, Clostridium botulinum A strain ATCC 3502
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