Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
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[Homology]
Score
fldBR-phenyllactate dehydratase medium subunit. (407 aa)    
Predicted Functional Partners:
fldC
R-phenyllactate dehydratase small subunit.
 
 
 
 0.968
fldI
R-phenyllactate dehydratase activator.
 
 
 0.959
fldA
E-cinnamoyl-CoA:R-phenyllactate CoA transferase large subunit; Belongs to the CoA-transferase III family.
 
   
 0.939
hadC
Subunit of oxygen-sensitive 2-hydroxyisocaproyl-CoA dehydratase.
 
 
 
 0.869
hadI
Activator of 2-hydroxyisocaproyl-CoA dehydratase.
 
 
 0.827
CBO3285
Conserved membrane protein.
 
     0.807
CBO2202
Putative bifunctional protein [includes; Similar over its N-terminal region to small subunits of 2-hydroxyacyl-CoA dehydratases (hadC, HgdB and FldC), and over its C-terminal region to activators of 2-hydroxyacyl-CoA dehydratases (HadI, hgdC and FldI). Possible bifunctional fusion protein.
 
 
 0.773
hadA
isocaprenoyl-CoA:2-hydroxyisocaproate CoA-transferase; This gene from C. difficile was cloned,overexpressed in E. coli, and characterized as 2-hydroxyisocaproate CoA-transferase, a class III enzyme (Kim et al. 2004. FEMS Microbiol. Rev. 28, 455-468); Belongs to the CoA-transferase III family.
 
   
 0.732
CBO2193
Putative membrane protein; CDS is extended at the C-terminus in comparison to similar proteins. N-terminal region is similar to Pyrococcus horikoshii hypothetical protein PH0137 SWALL:O57877 (EMBL:AP000001) (378 aa) fasta scores: E(): 6.4e-17, 26.5 38d in 381 aa.
 
     0.725
CBO3242
Activator of 2-hydroxyacyl-CoA dehydratase.
 
 
 0.632
Your Current Organism:
Clostridium botulinum A ATCC 3502
NCBI taxonomy Id: 413999
Other names: C. botulinum A str. ATCC 3502, Clostridium botulinum A str. ATCC 3502, Clostridium botulinum A strain ATCC 3502
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