STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
thyXThymidylate synthase complementing protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (252 aa)    
Predicted Functional Partners:
CBO0768
Putative phage-related deoxyuridylate hydroxymethyltransferase.
    
 0.957
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
   
 0.934
dut
Putative deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
    
 0.930
tmk
Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
    
 0.929
CBO0146
Putative zinc-binding protein; Similar to Clostridium tetani comE operon protein 2 ctc00309 SWALL:Q898X8 (EMBL:AE015936) (162 aa) fasta scores: E(): 6.7e-56, 81.48 38d in 162 aa, and to Clostridium acetobutylicum deoxycytidylate deaminase cac2876 SWALL:Q97F76 (EMBL:AE007785) (162 aa) fasta scores: E(): 1.9e-44, 67.28 38d in 162 aa.
 
  
  0.929
purN
Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
  
 
 0.924
tdK
Thymidine kinase; Similar to Rhodothermus sp. thymidine kinase Tdk SWALL:KITH_RHOSI (SWALL:Q9ZIG2) (213 aa) fasta scores: E(): 2.6e-34, 53.26 38d in 184 aa, and to Clostridium acetobutylicum thymidine kinase cac2887 SWALL:Q97F65 (EMBL:AE007786) (195 aa) fasta scores: E(): 5.1e-56,77.48 38d in 191 aa.
    
 0.921
purH
Bifunctional purine biosynthesis protein [includes: phosphoribosylaminoimidazolecarboxamide formyltransferase and IMP cyclohydrolase.
     
 0.917
folD
Putative methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
    
 0.913
gcvT
Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine.
     
 0.912
Your Current Organism:
Clostridium botulinum A ATCC 3502
NCBI taxonomy Id: 413999
Other names: C. botulinum A str. ATCC 3502, Clostridium botulinum A str. ATCC 3502, Clostridium botulinum A strain ATCC 3502
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