STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ABK78021.1Single-stranded DNA-binding replication protein A, large (70 kD) subunit; COG1599. (132 aa)    
Predicted Functional Partners:
pcn
DNA polymerase sliding clamp subunit (PCNA); Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family.
  
 0.776
ABK76661.1
Helicase-associated endonuclease for fork-structured DNA; COG1948.
  
 
 0.743
cdc6
Cdc6-related protein, AAA superfamily ATPase; Involved in regulation of DNA replication.
  
 
 0.734
ABK78335.1
Cdc46/Mcm DNA replication licensing factor ATPase; COG1241; Belongs to the MCM family.
   
 0.723
ABK77588.1
DNA repair exonuclease; COG0420.
  
  0.719
fen
5'-3' exonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Act [...]
  
 0.676
ABK77804.1
DNA polymerase elongation subunit (family B); COG0417.
  
 0.665
ABK77806.1
ERCC4-like helicase; COG1111.
    
 0.661
ABK77587.1
ATPase involved in DNA repair; COG0419.
  
 0.635
dnaG
Bacterial-type DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.
  
     0.618
Your Current Organism:
Cenarchaeum symbiosum
NCBI taxonomy Id: 414004
Other names: C. symbiosum A, Cenarchaeum symbiosum A
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