ABK78249.1 protein (Cenarchaeum symbiosum) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

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Score

ABK78249.1

C-5 cytosine-specific DNA methylase; COG0270; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (325 aa)

Predicted Functional Partners:

ABK78558.1

0.934

ABK78013.1

0.909

ABK78250.1

0.750

ABK78047.1

0.637

ABK78248.1

0.627

ABK77316.1

0.551

ABK78506.1

0.540

ABK78245.1

0.534

ABK78246.1

0.478

ABK78247.1

0.478

Your Current Organism:

Cenarchaeum symbiosum

NCBI taxonomy Id: 414004
Other names: C. symbiosum A, Cenarchaeum symbiosum A

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABK77316.1	ABK78249.1	CENSYa_0683	CENSYa_1631	DNA modification methylase; COG0863.	C-5 cytosine-specific DNA methylase; COG0270; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.551
ABK78013.1	ABK78249.1	CENSYa_1390	CENSYa_1631	S-adenosylhomocysteine hydrolase; COG0499; Belongs to the adenosylhomocysteinase family.	C-5 cytosine-specific DNA methylase; COG0270; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.909
ABK78013.1	ABK78558.1	CENSYa_1390	CENSYa_1950	S-adenosylhomocysteine hydrolase; COG0499; Belongs to the adenosylhomocysteinase family.	S-adenosylmethionine synthetase; COG0192.	0.859
ABK78047.1	ABK78249.1	CENSYa_1425	CENSYa_1631	DNA modification methylase; COG0863.	C-5 cytosine-specific DNA methylase; COG0270; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.637
ABK78245.1	ABK78246.1	CENSYa_1627	CENSYa_1628	Conserved hypothetical protein.	Conserved hypothetical protein.	0.587
ABK78245.1	ABK78247.1	CENSYa_1627	CENSYa_1629	Conserved hypothetical protein.	DNA helicase.	0.587
ABK78245.1	ABK78248.1	CENSYa_1627	CENSYa_1630	Conserved hypothetical protein.	Signal transduction histidine kinase; COG0642.	0.506
ABK78245.1	ABK78249.1	CENSYa_1627	CENSYa_1631	Conserved hypothetical protein.	C-5 cytosine-specific DNA methylase; COG0270; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.534
ABK78245.1	ABK78506.1	CENSYa_1627	CENSYa_1897	Conserved hypothetical protein.	GTPase; COG1100.	0.898
ABK78246.1	ABK78245.1	CENSYa_1628	CENSYa_1627	Conserved hypothetical protein.	Conserved hypothetical protein.	0.587
ABK78246.1	ABK78247.1	CENSYa_1628	CENSYa_1629	Conserved hypothetical protein.	DNA helicase.	0.943
ABK78246.1	ABK78248.1	CENSYa_1628	CENSYa_1630	Conserved hypothetical protein.	Signal transduction histidine kinase; COG0642.	0.782
ABK78246.1	ABK78249.1	CENSYa_1628	CENSYa_1631	Conserved hypothetical protein.	C-5 cytosine-specific DNA methylase; COG0270; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.478
ABK78247.1	ABK78245.1	CENSYa_1629	CENSYa_1627	DNA helicase.	Conserved hypothetical protein.	0.587
ABK78247.1	ABK78246.1	CENSYa_1629	CENSYa_1628	DNA helicase.	Conserved hypothetical protein.	0.943
ABK78247.1	ABK78248.1	CENSYa_1629	CENSYa_1630	DNA helicase.	Signal transduction histidine kinase; COG0642.	0.779
ABK78247.1	ABK78249.1	CENSYa_1629	CENSYa_1631	DNA helicase.	C-5 cytosine-specific DNA methylase; COG0270; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.478
ABK78248.1	ABK78245.1	CENSYa_1630	CENSYa_1627	Signal transduction histidine kinase; COG0642.	Conserved hypothetical protein.	0.506
ABK78248.1	ABK78246.1	CENSYa_1630	CENSYa_1628	Signal transduction histidine kinase; COG0642.	Conserved hypothetical protein.	0.782
ABK78248.1	ABK78247.1	CENSYa_1630	CENSYa_1629	Signal transduction histidine kinase; COG0642.	DNA helicase.	0.779

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Network Stats

number of nodes:

11

number of edges:

27

average node degree:

4.91

avg. local clustering coefficient:

0.763

expected number of edges:

10

PPI enrichment p-value:

1.13e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006898

Receptor-mediated endocytosis

5 of 9

2.73

4.69

1.43e-09

GO:0006897

Endocytosis

7 of 62

2.04

4.1

3.97e-10

GO:0072583

Clathrin-dependent endocytosis

3 of 7

2.62

2.19

8.78e-05

GO:0006886

Intracellular protein transport

4 of 245

1.2

0.61

0.0377

GO:0006810

Transport

8 of 1502

0.71

0.48

0.0124

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030276

Clathrin binding

6 of 15

2.59

5.49

1.89e-11

GO:0035615

Clathrin adaptor activity

3 of 6

2.69

2.32

5.36e-05

GO:0032051

Clathrin light chain binding

2 of 2

2.99

1.46

0.0023

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030136

Clathrin-coated vesicle

5 of 20

2.39

3.92

1.73e-08

GO:0030125

Clathrin vesicle coat

4 of 12

2.51

3.33

4.55e-07

GO:0030130

Clathrin coat of trans-Golgi network vesicle

3 of 4

2.86

2.98

3.36e-06

GO:0030132

Clathrin coat of coated pit

3 of 5

2.77

2.96

3.42e-06

GO:0031982

Vesicle

6 of 232

1.4

1.78

3.42e-06

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:9385

Mixed, incl. Clathrin binding, and AP-3 adaptor complex

8 of 49

2.2

5.79

6.15e-14

CL:9383

Mixed, incl. Membrane coat, and Dynamin-type guanine nucleotide-binding (G) domain

9 of 79

2.04

5.5

1.19e-14

CL:9390

Mixed, incl. AP-type membrane coat adaptor complex, and Clathrin binding

7 of 36

2.28

5.47

1.60e-12

CL:9392

AP-type membrane coat adaptor complex, and Clathrin binding

6 of 31

2.27

4.67

1.65e-10

CL:9427

Clathrin binding, and Eps15 homology domain

4 of 12

2.51

3.41

3.05e-07

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04144

Endocytosis

5 of 161

1.48

1.63

5.44e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8856828

Clathrin-mediated endocytosis

5 of 50

1.99

2.75

1.26e-06

MAP-199992

trans-Golgi Network Vesicle Budding

4 of 31

2.1

2.4

1.47e-05

MAP-437239

Recycling pathway of L1

3 of 8

2.56

2.36

4.03e-05

MAP-432720

Lysosome Vesicle Biogenesis

3 of 14

2.32

2.13

8.57e-05

MAP-373760

L1CAM interactions

3 of 15

2.29

2.12

8.81e-05

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0030118

Clathrin coat

3 of 10

2.47

1.96

0.00022

GOCC:0030136

Clathrin-coated vesicle

3 of 18

2.21

1.72

0.00052

GOCC:0030125

Clathrin vesicle coat

2 of 9

2.33

1.16

0.0072

GOCC:0031410

Cytoplasmic vesicle

4 of 208

1.27

0.87

0.0072

GOCC:0098796

Membrane protein complex

4 of 323

1.08

0.64

0.0211

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0968

Cytoplasmic vesicle

3 of 12

2.39

2.15

8.77e-05

KW-0168

Coated pit

2 of 3

2.81

1.61

0.0012

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