node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABK76747.1 | cdc6 | CENSYa_0102 | CENSYa_1839 | Single-stranded DNA-specific exonuclease; COG0608. | Cdc6-related protein, AAA superfamily ATPase; Involved in regulation of DNA replication. | 0.532 |
ABK76747.1 | polB | CENSYa_0102 | CENSYa_1840 | Single-stranded DNA-specific exonuclease; COG0608. | Archaeal DNA polymerase II, small subunit/DNA polymerase delta, subunit B; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family. | 0.824 |
ABK76747.1 | polC | CENSYa_0102 | CENSYa_1827 | Single-stranded DNA-specific exonuclease; COG0608. | Archaeal DNA polymerase II, large subunit; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase (By similarity). | 0.668 |
ABK77804.1 | cdc6 | CENSYa_1180 | CENSYa_1839 | DNA polymerase elongation subunit (family B); COG0417. | Cdc6-related protein, AAA superfamily ATPase; Involved in regulation of DNA replication. | 0.920 |
ABK77804.1 | dbh | CENSYa_1180 | CENSYa_0386 | DNA polymerase elongation subunit (family B); COG0417. | nucleotidyltransferase/DNA polymerase involved in DNA repair; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis. | 0.990 |
ABK77804.1 | fen | CENSYa_1180 | CENSYa_0270 | DNA polymerase elongation subunit (family B); COG0417. | 5'-3' exonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Act [...] | 0.985 |
ABK77804.1 | lig | CENSYa_1180 | CENSYa_1021 | DNA polymerase elongation subunit (family B); COG0417. | ATP-dependent DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. | 0.930 |
ABK77804.1 | pcn | CENSYa_1180 | CENSYa_1422 | DNA polymerase elongation subunit (family B); COG0417. | DNA polymerase sliding clamp subunit (PCNA); Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | 0.998 |
ABK77804.1 | polB | CENSYa_1180 | CENSYa_1840 | DNA polymerase elongation subunit (family B); COG0417. | Archaeal DNA polymerase II, small subunit/DNA polymerase delta, subunit B; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family. | 0.998 |
ABK77804.1 | priL | CENSYa_1180 | CENSYa_1926 | DNA polymerase elongation subunit (family B); COG0417. | Eukaryotic-type DNA primase, large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. | 0.999 |
ABK77804.1 | priS | CENSYa_1180 | CENSYa_1927 | DNA polymerase elongation subunit (family B); COG0417. | Eukaryotic-type DNA primase, catalytic (small) subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer exten [...] | 0.998 |
cdc6 | ABK76747.1 | CENSYa_1839 | CENSYa_0102 | Cdc6-related protein, AAA superfamily ATPase; Involved in regulation of DNA replication. | Single-stranded DNA-specific exonuclease; COG0608. | 0.532 |
cdc6 | ABK77804.1 | CENSYa_1839 | CENSYa_1180 | Cdc6-related protein, AAA superfamily ATPase; Involved in regulation of DNA replication. | DNA polymerase elongation subunit (family B); COG0417. | 0.920 |
cdc6 | fen | CENSYa_1839 | CENSYa_0270 | Cdc6-related protein, AAA superfamily ATPase; Involved in regulation of DNA replication. | 5'-3' exonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Act [...] | 0.795 |
cdc6 | lig | CENSYa_1839 | CENSYa_1021 | Cdc6-related protein, AAA superfamily ATPase; Involved in regulation of DNA replication. | ATP-dependent DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. | 0.465 |
cdc6 | pcn | CENSYa_1839 | CENSYa_1422 | Cdc6-related protein, AAA superfamily ATPase; Involved in regulation of DNA replication. | DNA polymerase sliding clamp subunit (PCNA); Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | 0.540 |
cdc6 | polB | CENSYa_1839 | CENSYa_1840 | Cdc6-related protein, AAA superfamily ATPase; Involved in regulation of DNA replication. | Archaeal DNA polymerase II, small subunit/DNA polymerase delta, subunit B; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family. | 0.762 |
cdc6 | polC | CENSYa_1839 | CENSYa_1827 | Cdc6-related protein, AAA superfamily ATPase; Involved in regulation of DNA replication. | Archaeal DNA polymerase II, large subunit; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase (By similarity). | 0.678 |
cdc6 | priL | CENSYa_1839 | CENSYa_1926 | Cdc6-related protein, AAA superfamily ATPase; Involved in regulation of DNA replication. | Eukaryotic-type DNA primase, large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. | 0.972 |
cdc6 | priS | CENSYa_1839 | CENSYa_1927 | Cdc6-related protein, AAA superfamily ATPase; Involved in regulation of DNA replication. | Eukaryotic-type DNA primase, catalytic (small) subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer exten [...] | 0.959 |