STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mptEUncharacterized Rossmann fold enzyme; Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl- 7,8-dihydropterin diphosphate (6-HMDP). (239 aa)    
Predicted Functional Partners:
ABK78611.1
Dihydropteroate synthase; COG0294.
    
 0.967
guaA
GMP synthase, PP-ATPase domain/subunit; Catalyzes the synthesis of GMP from XMP.
       0.589
ABK78608.1
Conserved hypothetical protein.
       0.588
guaB
IMP dehydrogenase/GMP reductase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
       0.549
ABK78609.1
Conserved hypothetical protein.
       0.548
ABK77598.1
Uncharacterized protein conserved in archaea; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).
  
     0.532
adkA
Archaeal adenylate kinase; COG2019; Belongs to the archaeal adenylate kinase family.
  
     0.510
ABK78093.1
Membrane protein; COG2237.
 
     0.507
aroK
Archaeal shikimate kinase; COG1685.
  
     0.506
ABK76662.1
Nucleic acid-binding protein; COG1439.
  
     0.483
Your Current Organism:
Cenarchaeum symbiosum
NCBI taxonomy Id: 414004
Other names: C. symbiosum A, Cenarchaeum symbiosum A
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.